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RAD21 Homolog (S. Pombe) Proteins (RAD21)

The protein encoded by RAD21 is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. Additionally we are shipping RAD21 Antibodies (60) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RAD21 5885 O60216
RAD21 19357 Q61550
Rat RAD21 RAD21 314949  
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Top RAD21 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days

RAD21 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for RAD21 Homolog (S. Pombe) (RAD21) Interaction Partners

Zebrafish RAD21 Homolog (S. Pombe) (RAD21) interaction partners

  1. The hearts of Rad21-depleted animals were smaller, often failed to loop, and functioned less efficiently than size-matched controls

  2. RAD21a suppression led to delayed intestinal transit and greatly reduced numbers of enteric neurons, similar to patients with chronic intestinal pseudo-o (show RUNX1 Proteins)bstructio (show APOB Proteins)n.

  3. Cohesin is a protein complex essential for sister chromatid cohesion and DNA repair that also appears to be essential for normal development through as yet unknown mechanisms.

Human RAD21 Homolog (S. Pombe) (RAD21) interaction partners

  1. Reduced RAD21 destabilizes high-level gene amplification by disrupting pre-replication complex bindings in human cancers with chromosomal instability.

  2. found well-positioned CTCF and RAD21 peaks approximately 60-80 bp upstream of the TSS in the unidirectional genes. The peak heights were related to the amount of antisense transcription. Results provide insights into the distribution of histone modifications at promoters and suggest a novel role of CTCF and cohesin as regulators of transcriptional direction.

  3. Studied the role of looping in large-scale (supra Mb) folding of human chromosomes by knocking down the gene that codes for CTCF and the one coding for Rad21, an essential subunit of cohesin.

  4. Elevated RAD21 expression tracks with reactivation of L1 expression in human sporadic colorectal cancer.

  5. Some patients with chronic intestinal pseudo-obstruction carry mutations in RAD21 that disrupt the ability of its product to regulate genes such as RUNX1 (show RUNX1 Proteins) and APOB (show APOB Proteins).

  6. CTCF (show CTCF Proteins) and Rad21 act as host cell restriction factors for Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication by modulating viral gene transcription.

  7. cohesin's proposed DNA exit gate is formed by interactions between Scc1 (show PTPRJ Proteins) and the coiled-coil region of Smc3 (show SMC3 Proteins).

  8. Cross-sectional deep-sequencing analysis for clonal hierarchy demonstrated STAG2 (show STAG2 Proteins), SMC3 (show SMC3 Proteins), and RAD21 mutations to be ancestral in 18%, 18%, and 47% of cases, respectively, and each expanded to clonal dominance concordant with disease transformation

  9. RAD21 expression in CRC is associated with aggressive disease especially in KRAS mutant tumours and resistance to chemoradiotherapy.

  10. This study reports the first intragenic deletion and frameshift mutations identified in RAD21 in two patients presenting with atypical Cornelia de Lange syndrome.

Mouse (Murine) RAD21 Homolog (S. Pombe) (RAD21) interaction partners

  1. Knockdown of Rad21 reduces expression of the constitutive, biallelically expressed Pcdhalpha isoforms alphac1 and alphac2.

  2. show that spermatocytes from mice lacking the two meiosis-specific cohesin subunits RAD21L (show RAD21L1 Proteins) and REC8 (show REC8 Proteins) were unable to initiate RAD51 (show RAD51 Proteins)- but not DMC1 (show DMC1 Proteins)-mediated double-strand break repair

  3. findings firmly establish a cell-division-independent role for cohesin in Tcra locus rearrangement and provide a comprehensive account of the mechanisms by which cohesin enables cellular differentiation

  4. knock-down of RAD21 causes expression changes that are similar to expression changes after Nanog (show NANOG Proteins) depletion, demonstrating the functional relevance of the RAD21--pluripotency transcriptional network association

  5. The signal of RAD21 was prominent in somatic cells outside the seminiferous tubules or in spermatogonia, and was also detected in some spermatocytes localizing away from the basement membrane.

  6. Rad21 is a DNA-damage response gene that markedly affects animal and cell survival

  7. a cohesin complex containing Rad21 and STAG2 cooperates with a STAG3-specific complex to maintain sister chromatid cohesion during the diplotene stage of meiosis

  8. Analyses of mRNA expression patterns of cohesin subunits Rad21 and Rec8 (show REC8 Proteins) in mice: germ cell-specific expression of rec8 (show REC8 Proteins) mRNA in both male and female mice.

  9. Rad21, and the superimposed SCP3 (show SYCP3 Proteins) and SCP2 (show CRISP3 Proteins), are involved in the monopolar attachment of sister kinetochores during meiosis I

RAD21 Protein Profile

Protein Summary

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells.

Gene names and symbols associated with RAD21

  • RAD21 homolog (S. pombe) (RAD21)
  • RAD21 homolog (S. pombe) a (rad21a)
  • 14S cohesin RAD21 subunit (rad21)
  • RAD21 homolog (S. pombe) (Rad21)
  • RAD21 homolog (S. pombe) (rad21)
  • CDLS4 protein
  • hHR21 protein
  • hr21 protein
  • HRAD21 protein
  • mcd1 protein
  • mKIAA0078 protein
  • nxp-1 protein
  • nxp1 protein
  • rad21 protein
  • scc1 protein
  • wu:fb55d02 protein
  • wu:fb93f04 protein
  • xrad21 protein

Protein level used designations for RAD21

double-strand-break repair protein rad21 homolog , RAD21 homolog (S. pombe) , SCC1 homolog , NXP-1 , nuclear matrix protein 1 , protein involved in DNA double-strand break repair , sister chromatid cohesion 1 , PW29 , pokeweed agglutinin-binding protein 29 , RAD21 homolog

100065497 Equus caballus
322275 Danio rerio
464346 Pan troglodytes
100350479 Oryctolagus cuniculus
100404485 Callithrix jacchus
100482392 Ailuropoda melanoleuca
100541813 Meleagris gallopavo
100594167 Nomascus leucogenys
399129 Xenopus laevis
5885 Homo sapiens
19357 Mus musculus
503676 Xenopus laevis
314949 Rattus norvegicus
420286 Gallus gallus
482021 Canis lupus familiaris
100154008 Sus scrofa
540966 Bos taurus
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