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RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1 Proteins (RHNO1)

Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Additionally we are shipping RHNO1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RHNO1 83695 Q9BSD3
RHNO1 72440  
Rat RHNO1 RHNO1 297627  
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Top RHNO1 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

RHNO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1 (RHNO1) Interaction Partners

Human RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1 (RHNO1) interaction partners

  1. Knockdown of RHINO in human cells partially abrogated ATR (show ANTXR1 Proteins)-Chk1 (show CHEK1 Proteins) kinase signaling following UV irradiation but did not impact the loading of Rad9 (show RAD9A Proteins)-Hus1 (show HUS1 Proteins)-Rad1 complex on chromatin or the association of Rad9 (show RAD9A Proteins)-Hus1 (show HUS1 Proteins)-Rad1 complex with TopBP1 (show TOPBP1 Proteins).

  2. Germline variation in the RHINO gene is unlikely to influence inherited susceptibility to breast cancer.

  3. We suggest that RHINO functions together with the 9-1-1 complex and TopBP1 to fully activate ATR (ataxia telangiectasia and Rad3-related.

  4. Identified C12orf32 to be significantly up-regulated in the great majority of clinical breast cancer specimens.

RHNO1 Protein Profile

Protein Summary

Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition of breat cancer cells. Plays a role in the stimulation of CHEK1 phosphorylation.

Gene names and symbols associated with RHNO1

  • RAD9-HUS1-RAD1 interacting nuclear orphan 1 (RHNO1)
  • RAD9-HUS1-RAD1 interacting nuclear orphan 1 (Rhno1)
  • similar to 5930416I19Rik protein (MGC94282)
  • 2510047L19Rik protein
  • 5930416I19Rik protein
  • C12orf32 protein
  • RHINO protein

Protein level used designations for RHNO1

RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 , Rad9, Rad1, Hus1 interacting nuclear orphan , rAD9, RAD1, HUS1-interacting nuclear orphan protein

GENE ID SPECIES
83695 Homo sapiens
72440 Mus musculus
297627 Rattus norvegicus
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