Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Additionally we are shipping RHNO1 Kits (3) and many more products for this protein.
Showing 2 out of 2 products:
Knockdown of RHINO in human cells partially abrogated ATR (show ANTXR1 Proteins)-Chk1 (show CHEK1 Proteins) kinase signaling following UV irradiation but did not impact the loading of Rad9 (show RAD9A Proteins)-Hus1 (show HUS1 Proteins)-Rad1 complex on chromatin or the association of Rad9 (show RAD9A Proteins)-Hus1 (show HUS1 Proteins)-Rad1 complex with TopBP1 (show TOPBP1 Proteins).
Germline variation in the RHINO gene is unlikely to influence inherited susceptibility to breast cancer.
We suggest that RHINO functions together with the 9-1-1 complex and TopBP1 to fully activate ATR (ataxia telangiectasia and Rad3-related.
Identified C12orf32 to be significantly up-regulated in the great majority of clinical breast cancer specimens.
Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition of breat cancer cells. Plays a role in the stimulation of CHEK1 phosphorylation.
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1
, Rad9, Rad1, Hus1 interacting nuclear orphan
, rAD9, RAD1, HUS1-interacting nuclear orphan protein