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RANBP3 encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. Additionally we are shipping RAN Binding Protein 3 Antibodies (76) and many more products for this protein.
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RANBP3 regulates melanoma cell proliferation and probably a potential target for molecular targeted therapy.
Results demonstrate that RanBP3L, as a nuclear exporter for BMP-specific Smads, plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation.
RanBP3 is involved in vRNP nuclear export. The function of RanBP3 during vRNP nuclear export is regulated by phosphorylation at Ser58. RanBP3 phosphorylation is modulated by both PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) and Ras/ERK (show EPHB2 Proteins)/RSK (show RPS6KA1 Proteins) pathways in the late phase of viral infection.
Crystal structure of the Ran-binding domain (RBD (show CACNA1D Proteins)) from RanBP3 and compare it to RBD (show CACNA1D Proteins) structures from RanBP1 (show RANBP1 Proteins) and RanBP2 in complex with Ran and CRM1 (show XPO1 Proteins).
RanBP3 stimulates export by enhancing the affinity of Crm1 (show XPO1 Proteins) for Ran-GTP (show AK3 Proteins) and cargo.
A multifunctional domain in CRM1 (exportin 1 (show XPO1 Proteins)) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein.
RANBP3 phosphorylation links the Ras and PI3-kinase (show PIK3CA Proteins) pathways to nucleocytoplasmic transport.
RanBP3 directly recognizes dephosphorylated Smad2 (show SMAD2 Proteins)/3, which results from the activity of nuclear Smad (show SMAD1 Proteins) phosphatases, and mediates nuclear export of Smad2 (show SMAD2 Proteins)/3 in a Ran-dependent manner.
Protein phosphatase PPM1A (show PPM1A Proteins) regulates the nuclear export of Smad2 (show SMAD2 Proteins)/3 through targeting nuclear exporter RanBP3.
This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
ran binding protein 3
, RAN binding protein 3
, ran-binding protein 3
, RAN-binding protein-3
, ran-binding protein 3-like