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RANBP9 encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex.
the role of RanBP9 in the brain
Down-regulation of importin 7 (show IPO7 ELISA Kits) suppresses lung tumorigenesis via suppressing Akt (show AKT1 ELISA Kits) activity and inducing apoptosis
A novel role of Ranbp9 in regulating alternative splicing in spermatogenic cells, which is critical for normal spermatogenesis and male fertility.
Data found that endogenous RanBP9 positively regulates SSH1 levels and mediates Abeta-induced translocation of cofilin to mitochondria and induction of cofilin-actin pathology in cultured cells, primary neurons, and in vivo
RanBP9 overexpression in APDeltaE9 mouse model of Alzheimer's disease further exacerbated the reductions in spine density in both the cortex and the hippocampus
results suggest that functional interactions between BM88/Cend1 (show CEND1 ELISA Kits), RanBPM and Dyrk1B (show DYRK1B ELISA Kits) affect the balance between cellular proliferation and differentiation in Neuro 2a cells
The AXL (show AXL ELISA Kits)/LRP-1 (show LRP1 ELISA Kits)/RANBP9 complex is used by dendritic cells to cross-present apoptotic cell-associated antigens to T cells.
RanBP9 overexpression in transgenic mice led to striking reduction in the levels of spinophilin (show PPP1R9B ELISA Kits).
RanBP9 physically interacts with the tumor suppressor p73 (show ARHGAP24 ELISA Kits) and increases endogenous p73alpha levels at both transcriptional and post-translational levels.
RanBP9-cofilin (show CFL1 ELISA Kits) pathway as critical therapeutic targets not only for stemming Abeta (show APP ELISA Kits) generation but also antagonizing Abeta (show APP ELISA Kits)-induced neurotoxicity.
RanBP9/TSSC3 (show PHLDA2 ELISA Kits) complex cooperatively suppress metastasis via downregulation of Src (show SRC ELISA Kits)-dependent Akt (show AKT1 ELISA Kits) pathway to expedite mitochondrial-associated anoikis.
Results show that increased expression of RanBPM associates with postponed disease progression and better prognosis suggesting that RanBPM plays an inhibitory role in regulating proliferation and invasion of lung cancer cells.
The 20-mer (show MERTK ELISA Kits) peptide (residues 228-247) of human DDX-4 (show DDX4 ELISA Kits), an ATP-dependent RNA helicase (show DDX52 ELISA Kits) known to regulate germ cell development, binds to a unique shallow binding surface on RanBPM formed by highly conserved loops on the surface of the beta-sheet with two aspartates on one end, a positive patch on the opposite end, and a tryptophan lining at the bottom of the surface.
RanBPM acts as a negative regulator of BLT2 (show LTB4R2 ELISA Kits) and IL8 (show IL8 ELISA Kits), thus attenuating the invasiveness of aggressive breast cancer cells
RanBP9 absence hampers the molecular mechanisms leading to efficient repair of damaged DNA, resulting in enhanced sensitivity to genotoxic stress.
Loss of RanBPM expression may play an important role in gastric cancer tumor development and metastasis. Reduced RanBPM expression is also associated with chemoresistance of gastric cancer cells.
RanBP9 is positively expressed in bone tumor tissues and cell strains.
RanBPM was found to enhance Zta-dependent transcriptional activity via the inhibition of Zta sumoylation.
association analyses between RANBP9 variants and the risk of schizophrenia were conducted, however no significant association was identified.
RanBP9 relocates APP (show APP ELISA Kits) intracellular domain to Tip60 (show KAT5 ELISA Kits)-enriched nuclear speckles and prevented the formation of nuclear spots formation; results place RanBP9 as an important player in the multiple steps of AbetaPP signaling
This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11.
ran-binding protein 9
, ran-binding protein M
, RAN binding protein 7
, ran-binding protein 7
, RAN binding protein 9
, RAN binding protein 10
, ran-binding protein 10
, ran binding protein 9
, Ran Binding Protein in the Microtubule organizing center
, novel centrosomal protein RanBPM
, ran binding protein, centrosomal
, B cell antigen receptor Ig beta associated protein 1
, B-cell antigen receptor Ig beta-associated protein 1
, RAN binding protein 9 a