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The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010].. Additionally we are shipping RAP1GDS1 Antibodies (47) and RAP1GDS1 Kits (3) and many more products for this protein.
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results indicate that statins selectively up-regulate SmgGDS in endothelial cells, for which the beta1-integrin/Akt1 (show AKT1 Proteins) pathway may be involved, demonstrating the novel aspects of the pleiotropic effects of statins
DiRas1 (show DIRAS1 Proteins) expression inhibits malignant features of cancers in part by nonproductively binding to SmgGDS and inhibiting the binding of other small GTPases to SmgGDS
SmgGDS promotes cell cycle progression in multiple types of cancer, making SmgGDS a valuable target for cancer therapeutics.
TG2 (show TGM2 Proteins) contributes to apoptosis induction in Jurkat T cells by modulating Ca2 (show CA2 Proteins)+ homeostasis via cross-linking RAP1GDS1.
findings identify SmgGDS-558 as an activator of RhoA (show RHOA Proteins) and NF-kB in breast cancer, and demonstrate a functional role for SmgGDS-558 in the proliferation of breast cancer cells and tumorigenesis.
this study provides evidence that SmgGDS-607 associates with GTPases through recognition of the last amino acid in the CAAX motif.
These results indicate that statins exert their pleiotropic effects through SmgGDS upregulation with a resultant Rac1 degradation and reduced oxidative stress in animals and humans.
findings provide compelling evidence of a novel role for junctional adhesion molecule-A (JAM-A (show F11R Proteins))in driving breast cancer cell migration via activation of Rap1 (show RABGEF1 Proteins) GTPase (show RACGAP1 Proteins) and beta1-integrin
Results indicate that SmgGDS is a bona fide GEF (show SLC2A4RG Proteins) that specifically activates RhoA (show RHOA Proteins) and RhoC (show RHOC Proteins) through a unique mechanism not used by other Rho family exchange factors.
Results indicate that guanine nucleotide exchange and interactions with SmgGDS splice variants can regulate the entrance and passage of PBR (show TSPO Proteins)-possessing small GTPases through the prenylation pathway.
These results identify SmgGDS as a novel regulator of myosin organization and contraction in vascular smooth muscle cells.
The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993
rap1 GTPase-GDP dissociation stimulator 1
, RAP1, GTP-GDP dissociation stimulator 1
, SMG GDS protein
, SMG P21 stimulatory GDP/GTP exchange protein
, exchange factor smgGDS
, ralB-binding protein A
, rap1 GTPase-GDP dissociation stimulator 1-A