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RAP1GAP encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. Additionally we are shipping RAP1 GTPase Activating Protein Proteins (4) and many more products for this protein.
Showing 10 out of 36 products:
Human Polyclonal RAP1GAP Primary Antibody for ICC, IF - ABIN4349349
Mulder, Björling, Jonasson, Wernérus, Hober, Hökfelt, Uhlén: Tissue profiling of the mammalian central nervous system using human antibody-based proteomics. in Molecular & cellular proteomics : MCP 2009
a proper level of Rap1 is crucial for heart morphogenesis and function.
the direct interaction between Rap1 and KRIT1 is required for KRIT1 (show TERF2IP Antibodies)function in (show KRIT1 Antibodies) cardiovascular development
results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity
Findings suggest that RAP1 GTPase activating protein (Rap1GAP) is an important tumor suppressor with high prognostic value in endometrioid adenocarcinoma (EAC (show CYLD Antibodies)).
Rap1GAP is ubiquitinated and degraded through proteasome pathway in mitosis. Rap1GAP interacts with PLK1 (show PLK1 Antibodies) in vivo.
this study demonstrates that USP48 (show USP48 Antibodies) controls the Ubiquitin/proteasome-system-dependent turnover of activated NF-kappaB (show NFKB1 Antibodies)/RelA (show NFkBP65 Antibodies) in the nucleus.
Northern blot analysis revealed a single USP31 (show USP31 Antibodies) transcript of approximately 4 kb, which was primarily expressed in the testis and lung.
The Overexpression of USP31 (show USP31 Antibodies) in HEK (show EPHA3 Antibodies) 293T cells inhibited TNFalpha (show TNF Antibodies), CD40 (show CD40 Antibodies), LMP1 (show PDLIM7 Antibodies), TRAF2 (show TRAF2 Antibodies), TRAF6 (show TRAF6 Antibodies) and IKKbeta (show IKBKB Antibodies)-mediated NF-kappaB (show NFKB1 Antibodies) activation, but did not inhibit Smad (show SMAD1 Antibodies)-mediated transcription activation.
kidney biopsies from glomerulosclerosis patients exhibited increased RAP1GAP, resulting in diminished glomerular RAP1 activation
data demonstrate a crucial role for the dynamic interaction between D3R and USP48 (show USP48 Antibodies) in the regulation of NHE3 (show SLC9A3 Antibodies) expression and function
findings identify Rap1GAP as a critical regulator of aggressive tumor cell behavior and suggest that the level of Rap1GAP expression influences the migratory mechanisms that are operative in tumor cells.
Results demonstrated that Rap1GAP promoted leukemia cell differentiation and apoptosis, but increased leukemia cell invasion in vitro.
increased podocyte expression of RAP1GAP contributes directly to podocyte dysfunction by a mechanism that involves loss of RAP1-mediated activation of beta1 integrin
Plexins are GTPase (show RACGAP1 Antibodies)-activating proteins for Rap (show LRPAP1 Antibodies) and are activated by induced dimerization
Ca2 (show CA2 Antibodies)+-dependent monomer and dimer formation switches CAPRI (show RASA4 Antibodies) Protein between Ras GTPase-activating protein (show RASA1 Antibodies) (GAP) and RapGAP activities
ERK activation by cAMP does not require RAP1
evidence of differential Krit1 (show KRIT1 Antibodies) and Rap1A (show RAP1A Antibodies) expression during mouse ontogenesis and suggest a more widespread functional significance of Krit1 (show KRIT1 Antibodies), not restricted to vascular endothelial cells.
Rap1 (show TERF2IP Antibodies) couples cAMP signaling to a distinct pool of p42 (show EPB42 Antibodies)/44MAPK regulating excitability, synaptic plasticity, learning, and memory.
Expression studies show that mr-gef (show RAPGEF5 Antibodies) is expressed by young neurons of the developing rodent CNS but not by progenitor cells in the ventricular zone (VZ).
down-regulation of Rap1 (show TERF2IP Antibodies) expression following somatostatin (show SST Antibodies) treatment is closely related to the diminished LFA-1 (show ITGAL Antibodies) expression
forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling
EGF (show EGF Antibodies)-induced activation of GTPase (show RACGAP1 Antibodies) Rap1 (show TERF2IP Antibodies) was sensitized in NIH3T3/EGFR (show EGFR Antibodies)-e3B1 (show ABI1 Antibodies) cells.
This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
GTPase activating protein 1
, GTPase activating protein Rap1-GAP
, RAP1, GTPase activating protein 1
, Rap1 GTPase-activating protein 1
, rap1 GTPase-activating protein 1
, Rap1, GTPase-activating protein 1
, deubiquitinating enzyme 48
, ubiquitin carboxyl-terminal hydrolase 48
, ubiquitin specific protease 31
, ubiquitin specific protease 48
, ubiquitin thioesterase 48
, ubiquitin thiolesterase 48
, ubiquitin-specific-processing protease 48