RAP1 GTPase Activating Protein Proteins (RAP1GAP)

RAP1GAP encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Additionally we are shipping RAP1 GTPase Activating Protein Antibodies (35) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RAP1GAP 5909 P47736
RAP1GAP 110351  
Rat RAP1GAP RAP1GAP 313644  
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Top RAP1 GTPase Activating Protein Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days

RAP1GAP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for RAP1 GTPase Activating Protein (RAP1GAP) Interaction Partners

Zebrafish RAP1 GTPase Activating Protein (RAP1GAP) interaction partners

  1. a proper level of Rap1 is crucial for heart morphogenesis and function.

  2. the direct interaction between Rap1 and KRIT1 is required for KRIT1 (show TERF2IP Proteins)function in (show KRIT1 Proteins) cardiovascular development

Human RAP1 GTPase Activating Protein (RAP1GAP) interaction partners

  1. results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity

  2. Findings suggest that RAP1 GTPase activating protein (Rap1GAP) is an important tumor suppressor with high prognostic value in endometrioid adenocarcinoma (EAC (show CYLD Proteins)).

  3. Rap1GAP is ubiquitinated and degraded through proteasome pathway in mitosis. Rap1GAP interacts with PLK1 in vivo.

  4. this study demonstrates that USP48 (show USP48 Proteins) controls the Ubiquitin/proteasome-system-dependent turnover of activated NF-kappaB (show NFKB1 Proteins)/RelA (show NFkBP65 Proteins) in the nucleus.

  5. Northern blot analysis revealed a single USP31 transcript of approximately 4 kb, which was primarily expressed in the testis and lung.

  6. The Overexpression of USP31 in HEK (show EPHA3 Proteins) 293T cells inhibited TNFalpha (show TNF Proteins), CD40 (show CD40 Proteins), LMP1 (show PDLIM7 Proteins), TRAF2 (show TRAF2 Proteins), TRAF6 (show TRAF6 Proteins) and IKKbeta (show IKBKB Proteins)-mediated NF-kappaB (show NFKB1 Proteins) activation, but did not inhibit Smad (show SMAD1 Proteins)-mediated transcription activation.

  7. kidney biopsies from glomerulosclerosis patients exhibited increased RAP1GAP, resulting in diminished glomerular RAP1 activation

  8. data demonstrate a crucial role for the dynamic interaction between D3R and USP48 (show USP48 Proteins) in the regulation of NHE3 (show SLC9A3 Proteins) expression and function

  9. findings identify Rap1GAP as a critical regulator of aggressive tumor cell behavior and suggest that the level of Rap1GAP expression influences the migratory mechanisms that are operative in tumor cells.

  10. Results demonstrated that Rap1GAP promoted leukemia cell differentiation and apoptosis, but increased leukemia cell invasion in vitro.

Mouse (Murine) RAP1 GTPase Activating Protein (RAP1GAP) interaction partners

  1. increased podocyte expression of RAP1GAP contributes directly to podocyte dysfunction by a mechanism that involves loss of RAP1-mediated activation of beta1 integrin

  2. Plexins are GTPase (show RACGAP1 Proteins)-activating proteins for Rap (show LRPAP1 Proteins) and are activated by induced dimerization

  3. Ca2 (show CA2 Proteins)+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (show RASA1 Proteins) (GAP) and RapGAP activities

  4. ERK activation by cAMP does not require RAP1

  5. evidence of differential Krit1 (show KRIT1 Proteins) and Rap1A (show RAP1A Proteins) expression during mouse ontogenesis and suggest a more widespread functional significance of Krit1 (show KRIT1 Proteins), not restricted to vascular endothelial cells.

  6. Rap1 (show TERF2IP Proteins) couples cAMP signaling to a distinct pool of p42 (show EPB42 Proteins)/44MAPK regulating excitability, synaptic plasticity, learning, and memory.

  7. Expression studies show that mr-gef (show RAPGEF5 Proteins) is expressed by young neurons of the developing rodent CNS but not by progenitor cells in the ventricular zone (VZ).

  8. down-regulation of Rap1 (show TERF2IP Proteins) expression following somatostatin (show SST Proteins) treatment is closely related to the diminished LFA-1 (show ITGAL Proteins) expression

  9. forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling

  10. EGF (show EGF Proteins)-induced activation of GTPase (show RACGAP1 Proteins) Rap1 (show TERF2IP Proteins) was sensitized in NIH3T3/EGFR (show EGFR Proteins)-e3B1 (show ABI1 Proteins) cells.

RAP1 GTPase Activating Protein (RAP1GAP) Protein Profile

Protein Summary

This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with RAP1GAP

  • RAP1 GTPase activating protein (LOC395647)
  • Rap1 GTPase-activating protein 1 (Tsp_09520)
  • RAP1 GTPase activating protein (rap1gap)
  • RAP1 GTPase activating protein (RAP1GAP)
  • Rap1 GTPase-activating protein (Rap1gap)
  • ubiquitin specific peptidase 48 (USP48)
  • 1300019I11Rik protein
  • 2310004O14Rik protein
  • AI427470 protein
  • DKFZp459A114 protein
  • RAP1 protein
  • Rap1ga1 protein
  • RAP1GAP protein
  • rap1gap1 protein
  • rap1gapii protein
  • rapgap protein
  • USP31 protein
  • zgc:175180 protein

Protein level used designations for RAP1GAP

GTPase activating protein 1 , GTPase activating protein Rap1-GAP , RAP1, GTPase activating protein 1 , Rap1 GTPase-activating protein 1 , rap1 GTPase-activating protein 1 , Rap1, GTPase-activating protein 1 , deubiquitinating enzyme 48 , ubiquitin carboxyl-terminal hydrolase 48 , ubiquitin specific protease 31 , ubiquitin specific protease 48 , ubiquitin thioesterase 48 , ubiquitin thiolesterase 48 , ubiquitin-specific-processing protease 48

395647 Gallus gallus
10902864 Trichinella spiralis
100144557 Danio rerio
100172787 Pongo abelii
5909 Homo sapiens
100538309 Danio rerio
494835 Xenopus laevis
532839 Bos taurus
110351 Mus musculus
313644 Rattus norvegicus
84196 Homo sapiens
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