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RIF1 encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1.
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Human Polyclonal RIF1 Primary Antibody for ELISA, WB - ABIN4350533
Wang, Zhao, Chen, Zhong, Liao, Gao, Cai, Lee, Li, Chowdhury, Yang, Pfeifer, Yen, Xu: Human RIF1 encodes an anti-apoptotic factor required for DNA repair. in Carcinogenesis 2009
Human Polyclonal RIF1 Primary Antibody for ELISA, WB - ABIN185304
Silverman, Takai, Buonomo, Eisenhaber, de Lange: Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint. in Genes & development 2004
Dog (Canine) Polyclonal RIF1 Primary Antibody for EIA, WB - ABIN401303
Adams, McLaren: Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells. in Developmental dynamics : an official publication of the American Association of Anatomists 2004
This study identifies Rif1 as the molecular link between nuclear architecture and replication-timing establishment in mammals.
Oct4 (show POU5F1 Antibodies) recruits Smad3 (show SMAD3 Antibodies) to bind to Rif1 promoter, but Smad3 (show SMAD3 Antibodies) joining facilitates the loading of a polycomb (show CBX2 Antibodies) complex that generates a repressive epigenetic modification on Rif1 promoter and maintains the expression of Rif1 in embryonic stem cells.
structural study of the mammalian Rif1
Rif1 negatively modulates Zscan4 (show ZSCAN4 Antibodies) expression by maintaining H3K9me3 levels at subtelomeric regions. Rif1 interacts and stabilizes H3K9 methylation complex.
Study concludes that 53BP1 (show TP53BP1 Antibodies) promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 and PTIP (show PAXIP1 Antibodies).
Rif1(-/-) mice are severely compromised for 53BP1 (show TP53BP1 Antibodies)-dependent class switch recombination (CSR (show SCARA3 Antibodies)) and fusion of dysfunctional telomeres.
data establish Rif1 as an important contributor to the control of double-strand break repair by 53BP1 (show TP53BP1 Antibodies)
study identifies Rif1 as an ATM (show ATM Antibodies) phosphorylation-dependent interactor of 53BP1 (show TP53BP1 Antibodies) and shows that absence of Rif1 results in 5'-3' DNA-end resection; Rif1 deficiency impairs DNA repair in cell cycle G(1) and S phases, interferes with immunoglobulin class switchnig and leads to accumulation of chromosome double strand breaks
Rif1 is a key regulator of the replication-timing programme in mammalian cells
Data indicate that Insl6 (show INSL6 Antibodies) is an injury-regulated myokine that functions as a myogenic regenerative factor.
These data reveal a thus far unrecognized function for Rif1 (show INSL6 Antibodies) in the resolution of ultrafine DNA bridges during anaphase to protect genomic integrity.
RIF1 (show INSL6 Antibodies) is an important component in DNA damage response signaling. [Review]
RIF1 not only acts downstream of 53BP1 and counteracts BRCA1-mediated end resection but also has a secondary role in promoting BLM function in DNA repair.
RIF1 (show INSL6 Antibodies) as the critical effector of 53BP1 (show TP53BP1 Antibodies) during DSB repair
Rif1 (show INSL6 Antibodies) plays crucial roles in determining the replication timing domain structures in human cells through regulating higher-order chromatin architecture
Rif1 (show INSL6 Antibodies) functions in the intra-S-phase checkpoint that serves to slow down DNA synthesis when DNA damage has occurred.
High RIF1 (show INSL6 Antibodies) expression is associated with breast tumors.
This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants.
insulin-like peptide 6
, insulin-like peptide INSL6
, relaxin/insulin-like factor 1
, RAP1 interacting factor homolog (yeast)
, telomere-associated protein RIF1
, telomere-associated protein RIF1-like
, rap1-interacting factor 1 homolog
, RAP1 interacting factor 1
, Rap1 interacting factor 1 homolog