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RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) ELISA Kits

The protein encoded by RASGRP2 is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. Additionally we are shipping RASGRP2 Antibodies (31) and RASGRP2 Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human RASGRP2 RASGRP2 10235 Q7LDG7
Anti-Rat RASGRP2 RASGRP2 361714 P0C643
Anti-Mouse RASGRP2 RASGRP2 19395 Q9QUG9
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More ELISA Kits for RASGRP2 Interaction Partners

Human RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) interaction partners

  1. Human CalDAG-GEFI (show RASGRP1 ELISA Kits) gene (RASGRP2) mutation affects platelet function and causes severe bleeding.

  2. phosphorylation of CalDAG-GEFI (show RASGRP1 ELISA Kits) is a critical mechanism by which PKA controls Rap1b (show RAP1B ELISA Kits)-dependent platelet aggregation

  3. RasGRP2 increases cell viability and cell-matrix adhesion through increased Ras expression and Rap1 activation, respectively, in endothelial cells.

  4. NIH3T3 cells were found nonpermissive to mtHSV but they became permissive following transformation with the Rasgrp2 gene. This effect was linked to the activation of the Ras-PKR (show PKLR ELISA Kits) signaling pathway.

  5. analyzed the 5'-flanking region of rasgrp2 gene by a luciferase assay, which revealed that not only a promoter but also silencer regions were present upstream of D1E, suggesting rasgrp2 expression is controlled by a combination of promotion and repression

  6. CalDAG-GEFI (show RASGRP1 ELISA Kits) plays a role in inside-out signaling to alphaIIbbeta3

Cow (Bovine) RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) interaction partners

Mouse (Murine) RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2) interaction partners

  1. (i) STIM1 (show STIM1 ELISA Kits)/SOCE is critical for procoagulant activity but not the proadhesive function of platelets; and (ii) at the site of vascular injury, STIM1 (show STIM1 ELISA Kits) and CalDAG-GEFI are critical for the first wave of thrombin (show F2 ELISA Kits) generation mediated by procoagulant platelets

  2. we evaluated the contribution of CalDAG-GEFI to platelet activation in a model of immune-mediated thrombocytopenia and thrombosis syndromes

  3. Studies indicate that CalDAG-GEFI mediates the rapid but reversible activation of integrin alphaIIbbeta3, and the adenosine diphosphate receptor P2Y12 (show P2RY12 ELISA Kits) facilitates delayed but sustained integrin activation.

  4. CalDAG-GEFI helps regulate neutrophil chemotaxis, independent of its established role in integrin activation, through a mechanism that involves actin cytoskeleton and cellular polarization.

  5. In a brain-slice explant model of Huntington's disease, knock-down of CalDAG-GEFI expression rescues striatal neurons from pathology induced by transfection of polyglutamine-expanded Htt (show HTT ELISA Kits) exon 1.

  6. CalDAG-GEFI plays a role in inside-out signaling to alphaIIbbeta3

  7. CalDAG-GEFI regulated the activation of beta(1) and beta(3) integrins in platelets, and CalDAG-GEFI deficiency caused complete inhibition of arterial thrombus formation.

  8. CalDAG-GEFI and PKC (show PKC ELISA Kits) represent separate, but synergizing, pathways important for alphaIIbbeta3 activation in platelets activated through the PAR4 (show F2RL3 ELISA Kits) receptor.

RASGRP2 Antigen Profile

Antigen Summary

The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with RASGRP2

  • RAS guanyl releasing protein 2 (RASGRP2) antibody
  • RAS guanyl releasing protein 2 (calcium and DAG-regulated) (RASGRP2) antibody
  • RAS guanyl releasing protein 2 (calcium and DAG-regulated) (Rasgrp2) antibody
  • RAS, guanyl releasing protein 2 (Rasgrp2) antibody
  • CalDAG-GEFI antibody
  • Caldaggef1 antibody
  • CDC25L antibody
  • RASGRP2 antibody

Protein level used designations for RASGRP2

RAS guanyl releasing protein 2 , RAS guanyl releasing protein 2, isoform 3 , F25B3.3 kinase-like protein , RAS guanyl nucleotide-releasing protein 2 , RAS guanyl-releasing protein 2 , calcium and DAG-regulated guanine nucleotide exchange factor I , calcium and diacylglycerol-regulated guanine nucleotide exchange factor I , cdc25-like protein , guanine exchange factor MCG7 , hCDC25L , RAS, guanyl releasing protein 2 , calDAG-GEFI , calcium diacylglycerol guanine nucleotide exchange factor I , CalDAG-GEFI , F25B3.3 kinase like protein , RAP 1A protein-specific guanine nucleotide exchange factor 1 , RAS, guanyl releasing protein 2; RAP 1A protein-specific guanine nucleotide exchange factor 1; CalDAG-GEFI

GENE ID SPECIES
100137599 Papio anubis
10235 Homo sapiens
361714 Rattus norvegicus
512056 Bos taurus
100328903 Oryctolagus cuniculus
19395 Mus musculus
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