You are viewing an incomplete version of our website. Please click to reload the website as full version.

RAS Guanyl Releasing Protein 4 Proteins (RASGRP4)

The protein encoded by RASGRP4 is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. Additionally we are shipping RAS Guanyl Releasing Protein 4 Antibodies (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RASGRP4 115727 Q8TDF6
RASGRP4 233046 Q8BTM9
RASGRP4 170668 Q8R5I4
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top RAS Guanyl Releasing Protein 4 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,971.00
Details

RASGRP4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for RAS Guanyl Releasing Protein 4 (RASGRP4) Interaction Partners

Human RAS Guanyl Releasing Protein 4 (RASGRP4) interaction partners

  1. Ras guanine nucleotide-releasing protein (show RCC1 Proteins) 4 is aberrantly expressed in the fibroblast-like synoviocytes of patients with rheumatoid arthritis and controls their proliferation.

  2. GPCR (show NMUR1 Proteins) activation of Ras and PI3Kc in neutrophils depends on PLCb2 (show PLCb2 Proteins)/b3 and the RasGEF RasGRP4.

  3. RasGRP4 plays a role in myeloid cell signaling growth regulation pathways that are responsive to diacylglycerol levels

  4. RasGRP4 is a cation-dependent, guanine nucleotide exchange factor (show RASGRF1 Proteins) and diacylglycerol/phorbol ester receptor that is selectively expressed in mast cells and their progenitors. RasGRP4 regulates the final stages of mast cell development.

  5. RasGRP4 regulates the expression of prostaglandin D2 in mast cells

  6. RasGRP4 translocates to varied intracellular compartments via its DAG/PMA-binding domain to regulate signaling pathways that control gene and protein expression in MCs (show SMCP Proteins), including the cell's ability to respond to IL-13 (show IL13 Proteins).

  7. RasGRP4 cooperates with AML1 mutations in T cell leukemogenesis as a class I mutation

Mouse (Murine) RAS Guanyl Releasing Protein 4 (RASGRP4) interaction partners

  1. RasGRP4 is required for CD117+ MCs (show SMCP Proteins) and DCs to optimally induce acute NK cell-dependent immune responses to LPS (show TLR4 Proteins) helps explain why this signaling protein has been conserved in evolution

  2. Rasgrp4 is an activity dependent gene in mouse olfactory sensory neurons. [Rasgrp4]

  3. GPCR (show GPBAR1 Proteins) activation of Ras and PI3Kc in neutrophils depends on PLCb2 (show PLCb2 Proteins)/b3 and the RasGEF RasGRP4.

  4. Ras guanine nucleotide-releasing protein (show RASGRF1 Proteins)-4 (RasGRP4) involvement in experimental arthritis and colitis.

  5. Despite high levels of RasGRP4 expression in mast cells, RasGRP4 deficiency led to only a modest reduction in FcepsilonRI (show FCER1A Proteins)-mediated degranulation and cytokine production.

  6. RasGRP4 cooperates with AML1 mutations in T cell leukemogenesis as a class I mutation

RAS Guanyl Releasing Protein 4 (RASGRP4) Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RASGRP4

  • RAS guanyl releasing protein 4 (RASGRP4)
  • RAS guanyl releasing protein 4 (rasgrp4)
  • RAS guanyl releasing protein 4 (LOC100350559)
  • RAS guanyl releasing protein 4 (Rasgrp4)
  • RASGRP4 protein

Protein level used designations for RASGRP4

RAS guanyl releasing protein 4 , RAS guanyl-releasing protein 4-like , RAS guanyl-releasing protein 4 , guanyl nucleotide releasing protein 4

GENE ID SPECIES
468867 Pan troglodytes
484528 Canis lupus familiaris
719595 Macaca mulatta
100013191 Monodelphis domestica
100101734 Xenopus (Silurana) tropicalis
100350559 Oryctolagus cuniculus
100390243 Callithrix jacchus
100444206 Pongo abelii
100590994 Nomascus leucogenys
115727 Homo sapiens
233046 Mus musculus
170668 Rattus norvegicus
529375 Bos taurus
Selected quality suppliers for RAS Guanyl Releasing Protein 4 Proteins (RASGRP4)
Did you look for something else?