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RAS P21 Protein Activator (GTPase Activating Protein) 1 Proteins (RASA1)

The protein encoded by RASA1 is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. Additionally we are shipping RASA1 Antibodies (95) and RASA1 Kits (17) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RASA1 5921 P20936
Rat RASA1 RASA1 25676 P50904
Mouse RASA1 RASA1 218397  
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Top RASA1 Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

RASA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

More Proteins for RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) Interaction Partners

Human RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) interaction partners

  1. PTP1B (show PTPN1 Proteins) dephosphorylates PITX1 (show PITX1 Proteins) to weaken its protein stability and the transcriptional activity for p120RasGAP gene expression

  2. Data suggest that, in response to netrin-1 (show NTN1 Proteins)/netrin receptor (DCC (show DCC Proteins)) signaling, p120RasGAP is recruited to growth cones and supports axon outgrowth; p120RasGAP Src (show SRC Proteins) homology 2 domains exhibit scaffolding properties sufficient to support axon outgrowth.

  3. Maternal and fetal capillary malformation-arteriovenous malformation due to a novel RASA1 mutation presenting with prenatal non-immune hydrops fetalis have been found.

  4. This is the second largest study on isolated, non-syndromic Port-wine stain; data suggest that GNAQ (show GNAQ Proteins) is the main genetic determinant in this condition. Moreover, isolated port-wine stains are distinct from capillary malformations seen in RASA1 disorders.

  5. Data showed that hypoxia regulated the expression of miR (show MLXIP Proteins)-182 and RASA1 to promote HCC (show FAM126A Proteins) angiogenesis.

  6. p120RasGAP shields Akt (show AKT1 Proteins) from deactivating phosphatases in FGF1 (show FGF1 Proteins) signaling, but loses this ability once cleaved by caspase-3 (show CASP3 Proteins).

  7. Capillary malformation-arteriovenous malformation syndrome (CM-AVM) is an autosomal dominant disorder caused by RASA1 mutations.

  8. Multifocal, small, round-to-oval, pinkish-to-red cutaneous capillary malformations are seen in more than 90% of people with RASA1 mutations.

  9. miR-21 promotes malignant behaviors of colon cancer cells by regulating RASA1 expression via RAS pathways.

  10. The individual contribution of each Akt (show AKT1 Proteins) isoform in p120 RasGAP fragment N-mediated cell protection against Fas ligand (show FASL Proteins) induced cell death, was investigated.

Cow (Bovine) RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) interaction partners

  1. The data suggest that nitrosylation of H-Ras (show HRAS Proteins) rearranges the adsorptive potential and intrinsic GTPase (show RACGAP1 Proteins) activity of H-Ras (show HRAS Proteins) through modification of C-terminal cysteines of molecule.

Mouse (Murine) RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1) interaction partners

  1. Double-deficient RASA1-neurofibromin 1 (show NF1 Proteins) mice developed T cell acute lymphoblastic leukemia/lymphoma, which originated at an early point in T cell development and was dependent on activating mutations in the Notch1 (show NOTCH1 Proteins) gene.

  2. Rasa1 may have a role in pathogenesis of capillary malformation-arteriovenous malformation in a mouse model

  3. Regulation of Rasa1 translation by miR (show MLXIP Proteins)-132 was seen in severed axons, demonstrating local function within the axon.

  4. RASA1 mutation is responsible for the aberrant lymphatic architecture and functional abnormalities, as visualized in the PKWS subject and in the animal model.

  5. MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA by repressing RAS p21 GTPase activating protein 1 (RASA1)

  6. 14-3-3 (show YWHAQ Proteins) negatively regulates the RGC downstream of the PI3-kinase (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway

  7. Caspase-3 (show CASP3 Proteins) is a stress intensity sensor that controls cell fate by either initiating a RasGAP cleavage-dependent cell resistance program or a cell suicide response mediated by akt (show AKT1 Proteins).

  8. Data reveal a role for RASA1 as a physiological negative regulator of lymphatic endothelial cell growth that maintains the lymphatic vasculature in a quiescent functional state through its ability to inhibit Ras signal transduction.

  9. Ca2 (show CA2 Proteins)+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP (show RAP1GAP Proteins) activities

  10. statins inhibit GGPP biosynthesis in the mevalonate pathway, and then inhibit signal transduction in the Ras/ERK (show EPHB2 Proteins) and Ras/Akt (show AKT1 Proteins) pathways, thereby inhibiting bFGF (show FGF2 Proteins), HGF (show HGF Proteins), TGF-beta (show TGFB1 Proteins) expression

RASA1 Protein Profile

Protein Summary

The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.

Gene names and symbols associated with RASA1

  • vacuolar peduncle (vap)
  • RAS p21 protein activator (GTPase activating protein) 1 (RASA1)
  • RAS p21 protein activator (GTPase activating protein) 1 (Rasa1)
  • RAS p21 protein activator 1 (Rasa1)
  • CG9209 protein
  • CM-AVM protein
  • CMAVM protein
  • D-RasGAP protein
  • Dmel\\CG9209 protein
  • Gap protein
  • GAPX protein
  • p120GAP protein
  • p120RASGAP protein
  • PKWS protein
  • RAS-GAP protein
  • Rasa protein
  • RASGAP protein

Protein level used designations for RASA1

CG9209-PA , CG9209-PB , CG9209-PC , CG9209-PD , Ras GTPase-activating protein , vacuolar peduncule , vacuolar pedunculi , vap-PA , vap-PB , vap-PC , vap-PD , ras GTPase-activating protein 1 , triphosphatase-activating protein , GAP , GTPase-activating protein , RAS p21 protein activator (GTPase activating protein RAS p21) , p120GAP , rasGAP , RAS p21 protein activator 1 , p120-rasGAP

32569 Drosophila melanogaster
5921 Homo sapiens
282032 Bos taurus
25676 Rattus norvegicus
427327 Gallus gallus
479158 Canis lupus familiaris
100627579 Sus scrofa
218397 Mus musculus
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