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The protein encoded by RASA2 is member of the GAP1 family of GTPase-activating proteins. Additionally we are shipping RASA2 Antibodies (22) and and many more products for this protein.
Recurrent inactivating RASA2 mutations are associated with melanoma.
GAP1m is a Ras GAP (show RASA1 ELISA Kits) that switches off Ras signalling. GAP1m undergoes a plasma membrane association following growth factor stimulation of PI 3 (show PI3 ELISA Kits)-kinase as a result of its PH domain binding to phosphatidylinositol 3,4,5-trisphosphate.
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member has a perinuclear localization and is an inositol 1,3,4,5-tetrakisphosphate-binding protein\; a compound suggested to function as a second messenger.
GTPase-activating protein 1m
, GTPase-activating protein of RAS
, ras GTPase-activating protein 2