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RASA4 encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Additionally we are shipping RASA4 Antibodies (9) and and many more products for this protein.
RASA4 isoform 2 promoter methylation correlated with clinical parameters predicting poor prognosis (older age, elevated fetal hemoglobin (show HBB ELISA Kits)), with higher risk of relapse after hematopoietic stem cell transplantation, and with PTPN11 (show PTPN11 ELISA Kits) mutation.
Ca2 (show CA2 ELISA Kits)+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (show RASA1 ELISA Kits) (GAP) and RapGAP (show RAP1GAP ELISA Kits) activities
CAPRI seems to low-pass filter the Ca2+ signal, converting different intensities of stimulation into different durations of Ras activity.
CAPRI (Ca2+-promoted Ras inactivator) a Ca2 (show CA2 ELISA Kits)+-dependent Ras GTPase-activating protein (Ras GAP (show RASA1 ELISA Kits)). Switches off the Ras-MAPK (show MAPK1 ELISA Kits) pathway following G protein-coupled receptor (show ADRA1A ELISA Kits) stimulated intracellular Ca2 (show CA2 ELISA Kits)+ elevation that recruits CAPRI to the plasma membrane.
Data show that calcium-promoted Ras inactivator (CAPRI) C2AB domains are required for CD28 antigen (show CD28 ELISA Kits) inhibition of adhesion.
deltaCAPRI regulates RANKL (show TNFSF11 ELISA Kits) shedding by modulating MMP14 (show MMP14 ELISA Kits) expression through Ras signaling cascades other than the Erk (show EPHB2 ELISA Kits) pathway
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
Ca2+-promoted Ras inactivator
, calcium-promoted Ras inactivator
, ras GTPase-activating protein 4
, rasGAP-activating-like protein 2
, Ca2+promoted Ras inactivator
, calcium-promoted RAS inactivator