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REST encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. Additionally we are shipping REST Antibodies (6) and and many more products for this protein.
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REST represses transcription of HIF-1alpha (show HIF1A ELISA Kits) in prolonged hypoxia, thus contributing to the resolution of the HIF-1alpha (show HIF1A ELISA Kits) response.
A role was determined for the NRSF-BDNF (show BDNF ELISA Kits) pathway in the modulation of cognitive function in patients with newly diagnosed epilepsy.
The splicing of REST by SRRM4 (show SRRM4 ELISA Kits) could promote the neuroendocrine phenotype in CRPC.
TSPYL2 (show TSPYL2 ELISA Kits) is an essential component of the REST/NRSF transcriptional complex for TGFbeta (show TGFB1 ELISA Kits) signaling activation
Cultured astrocytes gradually became refractory to reprogramming, in part by the repressor REST preventing Neurog2 (show NEUROG2 ELISA Kits) from binding to the NeuroD4 (show NEUROD4 ELISA Kits) promoter.
identified and validated a novel promoter of the MIR137 gene adjacent to miR (show MLXIP ELISA Kits)-137 itself which can direct the expression of distinct mRNA isoforms encoding miR (show MLXIP ELISA Kits)-137; internal promoter is regulated by repressor element-1 silencing transcription factor (REST)
Resveratrol via SIRT1 (show SIRT1 ELISA Kits)/c-Jun (show JUN ELISA Kits) downregulates REST mRNA and protein in SH-SY5Y cells.
Results demonstrate that REST regulates AF1q (show MLLT11 ELISA Kits) gene transcription through direct binding at -383 to -363 bp of AF1q (show MLLT11 ELISA Kits) promoter.
The results imply that NRSF/REST plays an important role in the survival of oral cancer cells by regulating the mTOR (show FRAP1 ELISA Kits) signaling pathway.
loss of REST induces a pathogenic program that works through the type 1 insulin (show INS ELISA Kits)-like growth factor receptor (show RYK ELISA Kits)/insulin receptor substrate 1 (show IRS1 ELISA Kits) pathway.
Detailed analysis of specific lineage markers expression showed selective downregulation of endoderm markers in REST-null cells, thus contributing to a loss of cardiogenic signals. REST regulates cardiac differentiation of ESCs (show NR2E3 ELISA Kits) by negatively regulating the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway and positively regulating the cardiogenic TF Gata4 (show GATA4 ELISA Kits)
The transcriptional repressor REST represses miR (show MLXIP ELISA Kits)-21 and, thus, regulates self-renewal in E14Tg2a.4 mESCs cultured in the absence of mouse embryonic fibroblast feeder cell effects.
Data suggest that Rest regulates early osteoblast differentiation via modulating Rest expression that is independent of Osx (show SP7 ELISA Kits) expression.
REST expression in nerve injury is decreased following alternative splicing which in turn controls PACAP (show ADCYAP1 ELISA Kits) expression.
We propose a mechanism for transcriptional activation in neurons that involves REST-guided targeting of TET3 (show TET3 ELISA Kits) to the DNA for directed 5hmC generation and NSD3 (show WHSC1L1 ELISA Kits)-mediated H3K36 trimethylation
miR (show MLXIP ELISA Kits)-9-mediated downregulation of the transcriptional repressor REST is essential for proper dendritic growth.
Genes under REST control are actively repressed in stem cells by a balance of the H3K4me3 mark and a repressor complex that relies on histone deacetylase (show HDAC1 ELISA Kits) activity.
p120-catenin (show CTNND1 ELISA Kits) regulates REST and CoREST (show Rcor2 ELISA Kits) and modulates mouse embryonic stem cell differentiation.
Rest knockout mice do not have proper gastric retention and the reduction of acetylcholinesterase (show AChE ELISA Kits) activity in NCC (show SLC12A3 ELISA Kits)-derived myenteric plexus in the stomach was detected.
The transcriptional repressor rest modulates hedgehog (show SHH ELISA Kits) signaling.
This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described
RE1-silencing transcription factor
, neural-restrictive silencer factor
, neuron restrictive silencer factor
, repressor binding to the X2 box
, zinc finger transcription factor REST protein
, RE-1 silencer of transcription