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RCOR1 encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. Additionally we are shipping CoREST Proteins (4) and CoREST Kits (1) and many more products for this protein.
Showing 10 out of 40 products:
Human Monoclonal CoREST Primary Antibody for IF, WB - ABIN968756
Andrés, Burger, Peral-Rubio, Battaglioli, Anderson, Grimes, Dallman, Ballas, Mandel: CoREST: a functional corepressor required for regulation of neural-specific gene expression. in Proceedings of the National Academy of Sciences of the United States of America 1999
Show all 3 references for ABIN968756
Human Polyclonal CoREST Primary Antibody for IHC, WB - ABIN2780965
Battaglioli, Andrés, Rose, Chenoweth, Rosenfeld, Anderson, Mandel: REST repression of neuronal genes requires components of the hSWI.SNF complex. in The Journal of biological chemistry 2002
Show all 2 references for ABIN2780965
Chicken Polyclonal CoREST Primary Antibody for WB - ABIN2775735
Abuhatzira, Makedonski, Kaufman, Razin, Shemer: MeCP2 deficiency in the brain decreases BDNF levels by REST/CoREST-mediated repression and increases TRKB production. in Epigenetics : official journal of the DNA Methylation Society 2008
Rcor1 knock-out monocytes exhibited extensive self-renewal associated with hematopoietic stem cell expansion.
The results suggest that LSD1 (show KDM1A Antibodies)/CoREST interacts with extranucleosomal DNA when it productively engages its nucleosome substrate.
results suggest that LSD1 (show KDM1A Antibodies)-CoREST functions as an ergonomic clamp (show PDZK1 Antibodies) that induces the detachment of the H3 histone (show HIST1H3B Antibodies) tail from the nucleosomal DNA to make it available for capture by the enzyme active site.
Genomic deletions in RCOR1 are associated with a specific gene expression signature and with unfavorable clinical outcomes in diffuse large B-cell lymphoma patients.
Data show that miR (show MLXIP Antibodies)-22 specifically interacts with the 3' UTRs of the Rcor1, Rgs2 (show RGS2 Antibodies) and HDAC4 (show HDAC4 Antibodies) mRNAs.
Gfi-1B p32 (show C1QBP Antibodies) isoform binds to Gfi-1B target gene promoters and associates with the LSD1 (show KDM1A Antibodies)-CoREST repressor complex more efficiently than the major Gfi-1B p37 (show CCNH Antibodies) isoform
the H3 binding pocket is a central target site to (i) switch off LSD1 (show KDM1A Antibodies) amino oxidase activity, thus H3-tail demethylation; (ii) block the competitive binding of transcription factors; and (iii) prevent chromatin anchoring to LSD1 (show KDM1A Antibodies)/CoREST.
The CoREST and REST are necessary and inimical for expression of herpes simplex virus genes.
Transciption factor SNAIL1 (show SNAI1 Antibodies) mimics the histone H3 (show HIST3H3 Antibodies) tail and binds to the histone demethylase (show MBD2 Antibodies) LSD1 (show KDM1A Antibodies)-transcription co-repressor (CoREST) complex. The crystal structure of the complex is given here.
Insight into the molecular basis of the interaction between scaffolding protein CoREST and histone deacetylase (show HDAC1 Antibodies) LSD1 (show KDM1A Antibodies) may suggest a new means of inhibiting LSD1 (show KDM1A Antibodies) activity by misdirecting the enzyme away from nucleosomal substrates.
In mature erythroid cells, a strong upsurge in Rcor3 (show RCOR3 Antibodies) and a sharp decline in Rcor1 (show Rcor2 Antibodies) levels counteract LSD1 (show KDM1A Antibodies)/Rcor1 (show Rcor2 Antibodies)/2-mediated differentiation.
Rcor1 (show Rcor2 Antibodies) promotes erythropoiesis by repressing hematopoietic stem cells and/or progenitor genes, as well as the genes and signaling pathways that lead to myeloid cell fate.
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).
REST corepressor 1