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RCOR1 encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. Additionally we are shipping CoREST Antibodies (40) and CoREST Proteins (4) and many more products for this protein.
Rcor1 knock-out monocytes exhibited extensive self-renewal associated with hematopoietic stem cell expansion.
The results suggest that LSD1 (show KDM1A ELISA Kits)/CoREST interacts with extranucleosomal DNA when it productively engages its nucleosome substrate.
results suggest that LSD1 (show KDM1A ELISA Kits)-CoREST functions as an ergonomic clamp (show PDZK1 ELISA Kits) that induces the detachment of the H3 histone (show HIST1H3B ELISA Kits) tail from the nucleosomal DNA to make it available for capture by the enzyme active site.
Genomic deletions in RCOR1 are associated with a specific gene expression signature and with unfavorable clinical outcomes in diffuse large B-cell lymphoma patients.
Data show that miR (show MLXIP ELISA Kits)-22 specifically interacts with the 3' UTRs of the Rcor1, Rgs2 (show RGS2 ELISA Kits) and HDAC4 (show HDAC4 ELISA Kits) mRNAs.
Gfi-1B p32 (show C1QBP ELISA Kits) isoform binds to Gfi-1B target gene promoters and associates with the LSD1 (show KDM1A ELISA Kits)-CoREST repressor complex more efficiently than the major Gfi-1B p37 (show CCNH ELISA Kits) isoform
the H3 binding pocket is a central target site to (i) switch off LSD1 (show KDM1A ELISA Kits) amino oxidase activity, thus H3-tail demethylation; (ii) block the competitive binding of transcription factors; and (iii) prevent chromatin anchoring to LSD1 (show KDM1A ELISA Kits)/CoREST.
The CoREST and REST are necessary and inimical for expression of herpes simplex virus genes.
Transciption factor SNAIL1 (show SNAI1 ELISA Kits) mimics the histone H3 (show HIST3H3 ELISA Kits) tail and binds to the histone demethylase (show MBD2 ELISA Kits) LSD1 (show KDM1A ELISA Kits)-transcription co-repressor (CoREST) complex. The crystal structure of the complex is given here.
Insight into the molecular basis of the interaction between scaffolding protein CoREST and histone deacetylase (show HDAC1 ELISA Kits) LSD1 (show KDM1A ELISA Kits) may suggest a new means of inhibiting LSD1 (show KDM1A ELISA Kits) activity by misdirecting the enzyme away from nucleosomal substrates.
In mature erythroid cells, a strong upsurge in Rcor3 (show RCOR3 ELISA Kits) and a sharp decline in Rcor1 (show Rcor2 ELISA Kits) levels counteract LSD1 (show KDM1A ELISA Kits)/Rcor1 (show Rcor2 ELISA Kits)/2-mediated differentiation.
Rcor1 (show Rcor2 ELISA Kits) promotes erythropoiesis by repressing hematopoietic stem cells and/or progenitor genes, as well as the genes and signaling pathways that lead to myeloid cell fate.
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).
REST corepressor 1