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REST Corepressor 1 Proteins (RCOR1)

RCOR1 encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. Additionally we are shipping CoREST Antibodies (40) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RCOR1 23186 Q9UKL0
RCOR1 217864 Q8CFE3
Rat RCOR1 RCOR1 314458  
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Top CoREST Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,202.83
Details

RCOR1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for REST Corepressor 1 (RCOR1) Interaction Partners

Human REST Corepressor 1 (RCOR1) interaction partners

  1. Rcor1 knock-out monocytes exhibited extensive self-renewal associated with hematopoietic stem cell expansion.

  2. The results suggest that LSD1 (show KDM1A Proteins)/CoREST interacts with extranucleosomal DNA when it productively engages its nucleosome substrate.

  3. results suggest that LSD1 (show KDM1A Proteins)-CoREST functions as an ergonomic clamp (show PDZK1 Proteins) that induces the detachment of the H3 histone (show HIST1H3B Proteins) tail from the nucleosomal DNA to make it available for capture by the enzyme active site.

  4. Genomic deletions in RCOR1 are associated with a specific gene expression signature and with unfavorable clinical outcomes in diffuse large B-cell lymphoma patients.

  5. Data show that miR (show MLXIP Proteins)-22 specifically interacts with the 3' UTRs of the Rcor1, Rgs2 (show RGS2 Proteins) and HDAC4 (show HDAC4 Proteins) mRNAs.

  6. Gfi-1B p32 (show C1QBP Proteins) isoform binds to Gfi-1B target gene promoters and associates with the LSD1 (show KDM1A Proteins)-CoREST repressor complex more efficiently than the major Gfi-1B p37 (show CCNH Proteins) isoform

  7. the H3 binding pocket is a central target site to (i) switch off LSD1 (show KDM1A Proteins) amino oxidase activity, thus H3-tail demethylation; (ii) block the competitive binding of transcription factors; and (iii) prevent chromatin anchoring to LSD1 (show KDM1A Proteins)/CoREST.

  8. The CoREST and REST are necessary and inimical for expression of herpes simplex virus genes.

  9. Transciption factor SNAIL1 (show SNAI1 Proteins) mimics the histone H3 (show HIST3H3 Proteins) tail and binds to the histone demethylase LSD1 (show KDM1A Proteins)-transcription co-repressor (CoREST) complex. The crystal structure of the complex is given here.

  10. Insight into the molecular basis of the interaction between scaffolding protein CoREST and histone deacetylase (show HDAC1 Proteins) LSD1 (show KDM1A Proteins) may suggest a new means of inhibiting LSD1 (show KDM1A Proteins) activity by misdirecting the enzyme away from nucleosomal substrates.

Mouse (Murine) REST Corepressor 1 (RCOR1) interaction partners

  1. In mature erythroid cells, a strong upsurge in Rcor3 (show RCOR3 Proteins) and a sharp decline in Rcor1 (show Rcor2 Proteins) levels counteract LSD1 (show KDM1A Proteins)/Rcor1 (show Rcor2 Proteins)/2-mediated differentiation.

  2. Rcor1 (show Rcor2 Proteins) promotes erythropoiesis by repressing hematopoietic stem cells and/or progenitor genes, as well as the genes and signaling pathways that lead to myeloid cell fate.

CoREST (RCOR1) Protein Profile

Protein Summary

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).

Gene names and symbols associated with REST Corepressor 1 Proteins (RCOR1)

  • REST corepressor 1 (RCOR1)
  • REST corepressor 1 (rcor1)
  • REST corepressor 1 (Rcor1)
  • serologically defined colon cancer antigen 3 (sdccag3)
  • 5730409O11 protein
  • 6720480E22Rik protein
  • AU042633 protein
  • COREST protein
  • D12Wsu95e protein
  • im:6904264 protein
  • mKIAA0071 protein
  • RCOR protein
  • rcor1 protein
  • si:dkey-46n18.7 protein
  • xcoREST protein
  • zgc:158607 protein

Protein level used designations for REST Corepressor 1 Proteins (RCOR1)

REST corepressor 1 , corest

GENE ID SPECIES
467562 Pan troglodytes
506525 Bos taurus
569294 Danio rerio
100555676 Anolis carolinensis
100605606 Nomascus leucogenys
23186 Homo sapiens
428911 Gallus gallus
612620 Canis lupus familiaris
217864 Mus musculus
314458 Rattus norvegicus
398247 Xenopus laevis
779179 Xenopus laevis
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