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RFP encodes a member of the tripartite motif (TRIM) family. Additionally we are shipping RFP Proteins (3) and many more products for this protein.
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Studied the expression of TRIM27 in normal ovarian and fallopian tube epithelial cells and in ovarian serous carcinoma cells; correlated TRIM27 expression with clinical and pathological parameters.
Study found that compared to healthy individuals, Trim27 was significantly upregulated in patien (show PTPN2 Antibodies)ts with Parkinson's disease
The neoplasm leading cell specific expression of integrin beta1 was posttranscriptionally regulated by the TRIM27/MRTF-B (show MKL2 Antibodies) complex in response to the loss of intercellular adhesion.
Authors observed rapid, ICP0-dependent loss of TRIM27 during HSV-1 infection.
RFP (show FPR2 Antibodies)-knockdown ovarian cancer cells exhibited lower carboplatin resistance than control cells. These findings suggest that RFP (show FPR2 Antibodies) could be a predictive marker for chemoresistance in ovarian cancer patients.
RFP (show FPR2 Antibodies)-mediated ubiquitination of PTEN (show PTEN Antibodies) modulates its effect on AKT (show AKT1 Antibodies) activation.
These findings provide a cellular and molecular function for MAGE-L2 (show MAGEL2 Antibodies)-TRIM27 in retrograde transport, including an unappreciated role of K63-linked ubiquitination and identification of an activating signal of the WASH regulatory complex.
Data conclude that TRIM27 negatively regulates NOD2 (show NOD2 Antibodies)-mediated signaling by degradation of NOD2 (show NOD2 Antibodies) and suggest that TRIM27 could be a new target for therapeutic intervention in NOD2 (show NOD2 Antibodies)-associated diseases.
TRIM27 expression is a modifier of cancer incidence and progression and is a potential target for intervention.
These findings provide a unique mechanism for regulating class II PI3Ks, and identify TRIM27 as a previously undescribed negative regulator of CD4 (show CD4 Antibodies) T cells.
TRIM27 inhibits VSV infection-induced type I IFN production by promoting TBK1 (show TBK1 Antibodies) degradation.
Ret finger protein works as a novel E3 ligase in the Pax7 (show PAX7 Antibodies)-mediated degradation of MyoD (show MYOD1 Antibodies) in response to skeletal muscle atrophy.
Data showed that Trim27 deficiency decreases apoptosis and protects dopaminergic neurons in MPTP (show PTPN2 Antibodies) poisoning, suggesting that Trim27 may be an effective potential target during the treatment of Parkinson's disease
The ubiquitination-deubiquitination cascade mediated by the TRIM27-USP7 (show USP7 Antibodies) complex plays an important role in TNF-alpha (show TNF Antibodies)-induced apoptosis.
study found that TRIM27 negatively regulates FcepsilonRI (show FCER1A Antibodies) activation of KCa3.1 (show KCNN4 Antibodies) and downstream signaling by ubiquitinating and inhibiting PI3KC2beta; findings identify TRIM27 as an important negative regulator of mast cells in vivo
Trim27(-/-) mice (n = 14) were resistant to chemically induced skin cancer development (eight [57.2%] of 14 mice were tumor free) compared with Trim27(+/+) wild-type littermates (n = 13) (one [7.7%] of 13 mice was tumor free).
Epc1 (show EPC1 Antibodies)-induced enhancements of SRF-dependent multinucleation, transactivation of the skeletal alpha-actin (show ACTA1 Antibodies) promoter, binding of SRF to the serum response element, and muscle-specific (show EIF3K Antibodies) gene induction were blocked by RFP.
results suggest that bHLH transcription factors are regulated by a previously undescribed interaction with RFP, which functions to recruit HDAC and/or Polycomb proteins and thus repress target genes of bHLH proteins
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein.
tripartite motif-containing 27
, ret finger protein
, RFP transforming protein
, RING finger protein 76
, tripartite motif protein TRIM27
, tripartite motif-containing protein 27
, zinc finger protein RFP
, tripartite motif protein 27
, ret finger protein 1