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RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009].. Additionally we are shipping RGMB Proteins (4) and RGMB Kits (1) and many more products for this protein.
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Human Polyclonal RGMB Primary Antibody for EIA, IHC (p) - ABIN356900
Schnichels, Conrad, Warstat, Henke-Fahle, Skutella, Schraermeyer, Julien: Gene expression of the repulsive guidance molecules/neogenin in the developing and mature mouse visual system: C57BL/6J vs. the glaucoma model DBA/2J. in Gene expression patterns : GEP 2007
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Data show that Dragon expression was increased in colon cancer tissues compared to control tissues in CAC (show CA2 Antibodies) mouse model and in human patients.
RGMB was down-regulation in non-small cell lung cancer.
Study highlights the potential importance of RGMb in propagating pro-angiogenic effects of HGF (show HGF Antibodies) and BMP-7 (show BMP7 Antibodies).
two RGMB ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 (show NEO1 Antibodies) receptors in a pH-dependent manner.
current data firstly revealed that RGMB may act as a negative regulator in breast cancer through BMP signaling
The expression of RGMA (show RGMA Antibodies), RGMB and RGMC (show HFE2 Antibodies) was evident in most examined prostate cancer cell lines, and also in the prostate cancer tissues
Reduced expression of RGMB in breast cancer was associated with breast cancer.
Data show that Dragon expression was increased in colon cancer tissues compared to control tissues in CAC (show SLC25A20 Antibodies) mouse model and in human patients.
RGMb is a novel binding partner for PD-L2 (show PDCD1LG2 Antibodies) and its engagement with PD-L2 (show PDCD1LG2 Antibodies) promotes respiratory tolerance.
Dragon may impair tubular epithelial integrity and induce epithelial apoptosis both in vitro and in vivo.
Strong expression of RGMa (show RGMA Antibodies), RGMb and Neogenin (show NEO1 Antibodies) protein was found on several major axon tracts such as the primary olfactory projections, anterior commissure and fasciculus retroflexus.
Our data suggest a positive modulatory contribution of RGMb and bone morphogenetic protein signaling to neurite extension in vitro and early axonal regrowth after nerve injury in vivo and a negative effect of Noggin (show NOG Antibodies).
Dragon is an important negative regulator of IL-6 expression in immune cells; Dragon-deficient mice may be a useful model for studying immune and inflammatory disorders.
A gene with promoter binding to the DNA binding domain of DRG11 (show DRGX Antibodies); encodes a conserved developmentally regulated membrane-associated glycosyl-phosphatidylinositol-anchored protein which promotes dorsal root ganglion neuron adhesion.
The direct interaction of DRAGON with bone morphogenetic protein (BMP) ligands and receptors indicates that it is a BMP co-receptor that potentiates BMP signaling.
Dragon protein modulates bone morphogenetic protein signaling in cells from reproductive tissues.
a higher expression of RGMa (show RGMA Antibodies), RGMb and neogenin (show NEO1 Antibodies) was found in the retinas of all glaucoma-affected mice; a higher RGMa (show RGMA Antibodies) and RGMb expression were detected in the optic nerves of glaucoma-affected DBA (show RPS19 Antibodies)/2J-mice older than 11M
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005
RGM domain family member B
, repulsive guidance molecule b
, repulsive guidance molecule B
, RGM domain family, member B
, RGM domain family, member B-like
, RGM domain family member B-like
, DRG11-responsive axonal guidance and outgrowth of neurite