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RIOK1 includes two alternatively spliced transcript variants, which encode different isoforms. Additionally we are shipping RIO Kinase 1 Antibodies (53) and RIO Kinase 1 Kits (6) and many more products for this protein.
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Human RIOK1 Protein expressed in Baculovirus infected Insect Cells - ABIN2006195
Widmann, Wandrey, Badertscher, Wyler, Pfannstiel, Zemp, Kutay: The kinase activity of human Rio1 is required for final steps of cytoplasmic maturation of 40S subunits. in Molecular biology of the cell 2012
Show all 2 references for ABIN2006195
methionine adenosyltransferase II alpha (MAT2A (show MAT2A Proteins)), and the arginine methyltransferase, PRMT5 (show PRMT5 Proteins), as vulnerable enzymes in cells with MTAP (show MTAP Proteins) deletion.
The RIO kinase fold generates a versatile ATPase enzyme, which in the case of Rio1 is activated following the Rio2 step to regulate one of the final 40S maturation events, at which time the 60S subunit is recruited for final quality control check.
These results imply that, in glioblastoma cells, constitutive Akt (show AKT1 Proteins) signaling drives RIO kinase overexpression, which creates a feedforward loop that promotes and maintains oncogenic Akt (show AKT1 Proteins) activity through stimulation of mTor (show FRAP1 Proteins) signaling.
RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln fo (show PRMT5 Proteins)r binding and modulates PRMT5 complex composit (show NCL Proteins)ion and substrate specificity.
Describes a function for human RIOK1 as a component of the protein arginine methyltransferase 5 (show PRMT5 Proteins) complex, conferring specificity for nucleolin (show NCL Proteins) as a methylation substrate.
This gene includes two alternatively spliced transcript variants, which encode different isoforms. The function of this gene has not been determined.
serine/threonine-protein kinase RIO1