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RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. Additionally we are shipping RNA Binding Motif Protein 38 Proteins (6) and RNA Binding Motif Protein 38 Kits (3) and many more products for this protein.
Showing 10 out of 27 products:
Cow (Bovine) Polyclonal RBM38 Primary Antibody for WB - ABIN2779112
Shu, Yan, Chen: RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript. in Genes & development 2006
Show all 2 references for ABIN2779112
Human Polyclonal RBM38 Primary Antibody for WB - ABIN527566
Huang, Jeong, Okamura, Sook-Kim, Zhu, Guerrero-Preston, Ratovitski: Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. in Cell cycle (Georgetown, Tex.) 2012
Chicken Polyclonal RBM38 Primary Antibody for IHC, WB - ABIN2779111
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
The data suggested that XSeb4R is a novel player in gene expression regulation, acting at the posttranscriptional level during ectoderm specification in Xenopus.
Ablation of XSeb4R activity results in impairment of endoderm and mesoderm formation, while ectopic expression of XSeb4R in ectodermal cells induces endodermal and mesodermal gene expression.
RBM38 and DND1 (show DND1 Antibodies) are repressed in primary acute myeloid leukemia (show BCL11A Antibodies), neutrophil differentiation is dependent on increased expression of both proteins, and they have a role in regulating p21(CIP1 (show CDKN1A Antibodies)) expression during acute promyelocytic leukemia (show PML Antibodies) differentiation
RNPC1 was found to be expressed in bladder, blood, brain, breast, colorectal, eye, head and neck, lung, ovarian, skin and soft tissue cancer. In 14 of the 94 tests, an association between RNPC1 gene expression and cancer prognosis was observed.
our data suggest that RBM38 is a novel translational regulator of HIF1alpha (show HIF1A Antibodies) under a hypoxic condition.
Suggest that RNPC1 had a potential function to play a tumor-suppressor role which may be a potential marker in the therapeutic and prognostic of breast cancer.
Data indicate that long non-coding RNA HOTAIR is functionally related to RNA binding motif protein 38 (RBM38).
RBM38 as novel transcriptional target of E2F1 (show E2F1 Antibodies) restricts E2F1 (show E2F1 Antibodies)-induced proliferation. Furthermore, this negative feedback loop seems to restrict tumor aggressiveness, thereby promoting survival of patients with cancer.
A role for RBM38 in regulating alternative splicing during erythroid differentiation.
Data suggest that RNPC1 is a critical regulator of Mdm2 (show MDM2 Antibodies).
GSK3 (show GSK3b Antibodies) promotes p53 (show TP53 Antibodies) mRNA translation through phosphorylation of RNPC1
knockdown of MIC-1 (show C18orf8 Antibodies) can decrease RNPC1-induced cell growth suppression.
Rbm38 deficiency markedly decreases the tumor penetrance in mice heterozygous for p53 (show TP53 Antibodies) via enhanced p53 (show TP53 Antibodies) expression.
knockdown of MIC-1 (show GDF15 Antibodies) can decrease RNPC1-induced cell growth suppression.
knockdown of p73 (show ARHGAP24 Antibodies) or p21 (show D4S234E Antibodies), another target of RNPC1, attenuates the inhibitory effect of RNPC1 on cell proliferation and premature senescence, whereas combined knockdown of p73 (show ARHGAP24 Antibodies) and p21 (show D4S234E Antibodies) completely abolishes it
a novel mechanism by which HuR (show ELAVL1 Antibodies) is regulated by RNPC1 via mRNA stability and HuR (show ELAVL1 Antibodies) is a mediator of RNPC1-induced growth suppression.
loss of RNPC1 in mouse embryonic fibroblasts increased the level of p53 (show TP53 Antibodies) protein, leading to enhanced premature senescence in a p53 (show TP53 Antibodies)-dependent manner
RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell- specific isoform of FGFR2 (By similarity). Plays a role in myogenic differentiation.
RNA binding motif protein 38
, RNA-binding protein 38
, RNA-binding motif protein 38
, RNA-binding region (RNP1, RRM) containing 1
, RNA-binding region containing 1
, RNA-binding protein XSeb4R
, RRM-type RNA-binding protein XSEB4R
, hypothetical protein
, CLL-associated antigen KW-5
, RNA-binding region-containing protein 1
, ssDNA-binding protein SEB4
, seb4 mRNA