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In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. Additionally we are shipping RNA-Binding Protein NOB1 Antibodies (45) and RNA-Binding Protein NOB1 Kits (4) and many more products for this protein.
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The results suggested that NOB1 is important in OSCC development and serves as a candidate indicator of aggressiveness and a therapeutic target of oral squamous cell carcinoma.
These results suggest that NOB1 may act as an important regulator in non-small cell lung cancer growth and could be a therapeutic target of nonsmall cell lung cancer.
Downregulation of miR (show MLXIP Proteins)-326 inhibited tumor proliferation and tumor metastasis by directly targeting NOB1 in colorectal carcinoma. Upregulation of miR (show MLXIP Proteins)-326 in CRC (show CALR Proteins) cells was revealed to be associated with a feedback loop involving downregulation of the NOB1.
Enhanced expression of NOB1 is related to poor overall survival and progression-free survival in patients with resected non-small cell lung cancer.
Enhanced expression of NOB1 gene plays an important role in the occurrence and development of NSCLC.
NOB1 is involved in the malignant transformation and tumorigenecity of human prostate cancer cells.
These findings suggest that NOB1 may be a potential prognostic indicator for PCa (show FLVCR1 Proteins).
NOB1 gene silencing by lentivirus-mediated RNA interference can inhibit tumor growth by inducing apoptosis of cancerous human colorectal cells.
NOB1 protein in gastric cancer tissue and adjacent normal tissue was diffusely expressed in the cytoplasm and nucleus. NOB1 protein and mRNA expression was higher than normal in gastric cancer tissue and was directly related to tumor size.
Downregulation of NOB1 was able to significantly activate constitutive phosphorylation of p38 MAPK (show MAPK14 Proteins), which might contribute to the inhibition of papillary thyroid carcinoma cell growth.
In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009
NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
, nin one binding protein
, RNA-binding protein nob1
, RNA-binding protein NOB1
, PSMD8 binding protein 1
, adenocarcinoma antigen recognized by T lymphocytes 4
, phosphorylation regulatory protein HP-10
, protein ART-4
, likely ortholog of mouse nin one binding protein