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RSPO1 is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. Additionally we are shipping R-Spondin 1 Antibodies (68) and R-Spondin 1 Kits (28) and many more products for this protein.
Showing 10 out of 24 products:
Mouse (Murine) RSPO1 Protein expressed in CHO Cells - ABIN2007651
Binnerts, Kim, Bright, Patel, Tran, Zhou, Leung, Liu, Lomas, Dixon, Hazell, Wagle, Nie, Tomasevic, Williams, Zhan, Levy, Funk, Abo: R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 2 Pubmed References
Results showed that Rspo1 expression is downregulated in adult follicles but its activation is sufficient in promoting ovarian tumors supporting its direct involvement in the initiation of ovarian cancers.
We highlight the cooperation of WNT4 (show WNT4 Proteins), RSPO1 and FOXL2 (show FOXL2 Proteins) within a regulatory network and the need for further research to better understand their role in defining and maintaining ovarian identity.
Rspo1 glycosylation at Asn137 is essential for secretion and stability but not for heparin binding.
DPY19L3-mediated C-mannosylation of Rspo1 at tryptophan(156) is required for Rspo1 secretion.
Genetic variants in ZC3H11B, RSPO1, and GJD2 are associated with susceptibility to the development of high myopia in a Han Chinese population.
R-Spondin1 has an effect on radiosensitivity of glioma cells
ZNRF3 (show ZNRF3 Proteins) and LGR4 (show LGR4 Proteins)-binding sites in RSPO1 are required for Wnt (show WNT2 Proteins) signaling.
Changes in the expression levels of IRS1 (show IRS1 Proteins), IRS2 (show IRS2 Proteins), RIPK2 (show RIPK2 Proteins), RSPO1, and DNA JC15 genes might contribute to the development of insulin (show INS Proteins) resistance and glucose intolerance in the obese boys.
the LGR4-Rspo1 complex crystal structure shows divergent mechanisms of ligand recognition by leucine-rich repeat G-protein-coupled receptors
ZNRF3 (show ZNRF3 Proteins) binds RSPO1 and LGR5 (show LGR5 Proteins)-RSPO1 with micromolar affinity via RSPO1 furin (show FURIN Proteins)-like 1 (Fu1) domain.
In Rspo1 knock-out mice during pregnancy, a stronger expression of mesenchymal markers was observed, without modifications to the structure of mammary epithelial tissue. Mammary epithelial cell immunohistochemical analysis revealed a persistence of virgin markers, which signify a delay in cell differentiation.
RSPO-LGR4 (show LGR4 Proteins)/5-ZNRF3 (show ZNRF3 Proteins)/RNF43 (show RNF43 Proteins) module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.
Rspo1 and its receptor of leucine-rich repeat containing G-protein-coupled receptor 4 (Lgr4 (show LGR4 Proteins)) should be a novel molecular signal in the transmission of mechanical stimuli to biological signal in the bone, and this signal should be in the upstream of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling for bone formation.
We also show that R-spondin1 is depleted in RANK-null progenitors, and that its exogenous administration rescues key aspects of RANK deficiency by reinstating a WNT (show WNT2 Proteins) response and mammary cell expansion
R-spondin 1/dickkopf-1 (show DKK1 Proteins)/beta-catenin (show CTNNB1 Proteins) machinery is involved in testicular embryonic angiogenesis
The ascl2 (show ASCL2 Proteins) is regulated in a direct autoactivatory loop, leading to a distinct on/off expression pattern, and Wnt (show WNT2 Proteins)/R-spondin can activate this regulatory loop.
RSPO1, WNT4 (show WNT4 Proteins), and beta-catenin (show CTNNB1 Proteins) have roles in the signaling pathway during ovarian differentiation in mice.
Rspo1 is required for ovarian differentiation by activation of the WNT (show WNT2 Proteins)/CTNNB1 (show CTNNB1 Proteins) signalling pathway
Rspo1 is involved in maintenance of the immature state of the progenitors of the granulosa cells of the ovary
this study identifies Rspo1 and Wnt4 (show WNT4 Proteins) as two new regulators of cell proliferation in the early gonad regardless of its sex, in addition to the specific role of these genes in ovarian differentiation.
This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.
, roof plate-specific spondin-1
, ovarian R-spondin member 1
, cysteine-rich and single thrombospondin domain-containing protein 3
, thrombospondin type 1 domain containing gene Rspondin