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R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1\; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008].. Additionally we are shipping R-Spondin 2 Antibodies (26) and R-Spondin 2 Kits (4) and many more products for this protein.
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Human RSPO2 Protein expressed in Human Cells - ABIN2005415
Cadieu, Neff, Quignon, Walsh, Chase, Parker, Vonholdt, Rhue, Boyko, Byers, Wong, Mosher, Elkahloun, Spady, André, Lark, Cargill, Bustamante, Wayne, Ostrander: Coat variation in the domestic dog is governed by variants in three genes. in Science (New York, N.Y.) 2009
Show all 2 references for ABIN2005415
Mouse (Murine) RSPO2 Protein expressed in Human Cells - ABIN2008573
Kazanskaya, Glinka, del Barco Barrantes, Stannek, Niehrs, Wu: R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. in Developmental cell 2004
Show all 2 references for ABIN2008573
Rspo2 was found to have a negative regulatory effect during oxidized low density lipoproteininduced macrophage apoptosis by regulating lipid uptake.
data reveal a RSPO2-induced, LGR5 (show LGR5 Proteins)-dependent Wnt (show WNT2 Proteins) signaling-negative feedback loop that exerts a net growth-suppressive effect on CRC (show CALR Proteins) cells
results suggest that the expression of RSPO (show RSPO1 Proteins) fusion transcripts is related to a subset of colorectal cancers arising in the Japanese population
Wnt (show WNT2 Proteins)(high) cells were more likely to give rise to Wnt (show WNT2 Proteins)(high) progeny, tended to be more metastatic, and revealed higher levels of RSPO2 expression.
These findings suggest that R-Spondin2 may promote hepatic stellate cell activation by enhancing the canonical Wnt (show WNT2 Proteins) pathway.
using RNA-seq data, identification of multiple fusion transcripts including recurrent gene fusions involving R-spondin family members RSPO2 and RSPO3 (show RSPO3 Proteins) that together occur in 10% of colon tumours
Reduced Rspo-2 levels in osteoarthritis osteoblasts are responsible, at least in part, for their reduced Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling and abnormal mineralization.
LGR4 (show LGR4 Proteins) acted as a key receptor for Rspo2 to promote osteogenesis.
Rspo2 activates Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling to reduce Col2a1 (show COL2A1 Proteins) and Sox9 (show SOX9 Proteins) and to facilitate differentiation of proliferating chondrocytes into hypertrophic chondrocytes in growth cartilage
High resolution crystal structure of an ectodomain variant of human LGR5 (show LGR5 Proteins) (hLGR5ecto) complexed with a signalling competent fragment of mouse Rspo2.
The endogenously expressed Lgr4 (show LGR4 Proteins) may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin (show NDP Proteins)-mediated Lgr4 (show LGR4 Proteins)-Wnt (show WNT2 Proteins) signaling during gonadal development.
identify the transforming growth factor beta antagonist follistatin (show FST Proteins) as a key mediator of RSPO (show RSPO1 Proteins)-LGR4 (show LGR4 Proteins) signaling in myogenic differentiation
Rspo2 is required to limit the number of outer hair cells to three rows and for optimal arrangement of peripheral nerve fibers in the developing cochlea.
Rspo2 mutation in combination with Rspo3 (show RSPO3 Proteins) mutation causes severe limb truncation.
Recombinant R-spondin2 and Wnt3a (show WNT3A Proteins) up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells.
Results indicate that Rspo2 and Wnt1 (show WNT1 Proteins) have mutually distinct effects on mammary epithelial cell growth and these effects are context-dependent.
R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1\; MIM 116806) signaling (Kim et al., 2006
, roof plate-specific spondin-2
, activator of Wnt/beta-catenin pathway
, R-spondin 2 homolog
, R-spondin 2
, cysteine-rich and single thrombospondin domain-containing protein 2