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Rab Interacting Lysosomal Protein Proteins (RILP)

RILP encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Additionally we are shipping RILP Antibodies (13) and RILP Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RILP 83547 Q96NA2
RILP 280408 Q5ND29
Rat RILP RILP 287531  
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Top RILP Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RILP Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

Mouse (Murine)

More Proteins for Rab Interacting Lysosomal Protein (RILP) Interaction Partners

Human Rab Interacting Lysosomal Protein (RILP) interaction partners

  1. RILP suppresses the invasion of breast cancer cells by interacting with RalGDS (show RALGDS Proteins) to inhibit its guanine nucleotide exchange factor (show RASGRF1 Proteins) activity for RalA (show rala Proteins).

  2. RILP regulates vacuolar ATPase through interaction with the V1G1 subunit

  3. VPS41 (show VPS41 Proteins) subunit of HOPS (show ALPL Proteins) complex was defined to be the major partner for interacting with RILP.

  4. RILP regulates the activity of the V-ATPase (show ATP6V1H Proteins) through its interaction with V1G1.

  5. RILP directly and concomitantly binds the tethering HOPS (show ALPL Proteins) complex and the p150(Glued (show DCTN1 Proteins)) subunit of the dynein motor. ORP1L then functions as a cholesterol-sensing switch controlling RILP-HOPS (show ALPL Proteins)-p150(Glued (show DCTN1 Proteins)) interactions.

  6. Unique region in RILP responsible for its specific role in regulating lysosomal morphology as well as in its interaction with Rab7 (show RAB7B Proteins) and Rab34 (show RAB34 Proteins).

  7. The crystal structure of Rab7 (show RAB7B Proteins)-GTP (show AK3 Proteins) in complex with the Rab7 (show RAB7B Proteins) binding domain of RILP reveals that Rab7 (show RAB7B Proteins) interacts with RILP specifically via two distinct areas.

  8. The data together indicate that RILP, as already demonstrated for several other Rab (show HRB Proteins) effector proteins, is capable of self-association, thus probably forming a homo-dimer.

  9. RILP indeed prenylated, while phosphorylation analysis showed that the two protein kinase A sites are phosphorylated.

  10. Hence, RILPsv provides an extra dimension to the control of vesicle fusion and transport by the small GTPase (show RACGAP1 Proteins) Rab7 (show RAB7B Proteins).

Mouse (Murine) Rab Interacting Lysosomal Protein (RILP) interaction partners

  1. A new mechanism by which the dynein-dynactin (show DCTN1 Proteins) motor complex recognizes Mreg (show MREG Proteins) on mature melanosomes is revealed through interaction with RILP and is involved in the centripetal movement of melanosomes.

  2. Rab36 (show RAB36 Proteins) mediates retrograde melanosome transport in melanocytes through interaction with RILP.

  3. CD63 (show CD63 Proteins), but not RILP, is recruited to the phagosomes in macrophages expressing the dominant negative form of Rab7 (show RAB7A Proteins).

RILP Protein Profile

Protein Summary

This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology.

Gene names and symbols associated with RILP

  • Rab interacting lysosomal protein (RILP)
  • Rab interacting lysosomal protein (rilp)
  • Rab interacting lysosomal protein (Rilp)
  • AI835553 protein
  • Gm857 protein
  • MGC154468 protein
  • RILP protein
  • RP23-384C18.10 protein

Protein level used designations for RILP

Rab interacting lysosomal protein , rab-interacting lysosomal protein

GENE ID SPECIES
417558 Gallus gallus
480649 Canis lupus familiaris
750412 Pan troglodytes
779264 Xenopus laevis
783642 Bos taurus
100127814 Xenopus (Silurana) tropicalis
83547 Homo sapiens
280408 Mus musculus
287531 Rattus norvegicus
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