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human homolog is a member of a protein complex that regulates endosome fusion. Additionally we are shipping Rabaptin, RAB GTPase Binding Effector Protein 1 Antibodies (21) and and many more products for this protein.
The results contradict the model of feedback activation of Rab5 (show RAB5A ELISA Kits) and instead indicate that Rbpt5 is recruited by both Rabex5 (show RABGEF1 ELISA Kits) recognizing ubiquitylated cargo and by Rab4 (show RAB4A ELISA Kits) to activate Rab5 (show RAB5A ELISA Kits) in a feed-forward manner.
ITSN2L interacts with RABEP1 and stimulates its degradation in regulation of endocytosis.
The pleckstrin (show PLEK ELISA Kits) homology domain (PH) of PLD1 itself promotes degradation of HIF-1alpha (show HIF1A ELISA Kits), then accelerates EGFR (show EGFR ELISA Kits) endocytosis via upregulation of rabaptin-5 and suppresses tumor progression.
analysis of Rabex-5 (show RABGEF1 ELISA Kits) GEF activation by Rabaptin-5
The disruption of Rabaptin-5 Ser407 phosphorylation reduces persistent cell migration in 2D and alphavbeta3-dependent invasion.
Silencing of Rabaptin-5 induces down-regulation of recycling of K(V)10.1 channel in transfected cells and reduction of K(V)10.1 current density in cells natively expressing K(V)10.1, indicating a role of Rabaptin-5 in channel trafficking.
Breast cancer cell line studies showed that microRNA, miR (show MLXIP ELISA Kits)-373, was capable of promoting breast cancer invasion and metastasis via translational inhibition of TXNIP (show TXNIP ELISA Kits) and RABEP1 that were the direct target genes of miR (show MLXIP ELISA Kits)-373.
GGAs, a family of Arf-dependent clathrin adaptors involved in selection of TGN (show TG ELISA Kits) cargo, interact with the Rabaptin-5-Rabex-5 (show RABGEF1 ELISA Kits) complex, a Rab4 (show RAB4A ELISA Kits)/Rab5 (show RAB5A ELISA Kits) effector regulating endosome fusion
The authors determined that increased listeriolysin O-independent dissolution of vacuoles during RABEP1 knockdown required the Listeria monocytogenes broad-range phospholipase C (show PLC ELISA Kits) (PC-PLC (show HSPG2 ELISA Kits)).
novel protein complex composed of Rabep1, GGA1 (show GGA1 ELISA Kits) and Arl3 is responsible for the sorting and targeting of the polycystin 1 (show PKD1 ELISA Kits) andpolycystin 2 to the cilium.
The intracellular localization of Rabaptin-5gamma indicates that it is not involved in Rab5 (show RAB5A ELISA Kits)-driven events--rather, it functions in other membrane transport steps; role of alternative splicing in determination of functional activities of Rab (show HRB ELISA Kits) effector molecules
our results assign Rab5 (show RAB5A ELISA Kits) a key role in mediating mast cell secretory granule fusion during biogenesis
Rabex-5 (show RABGEF1 ELISA Kits) regulates neurite morphogenesis of hippocampal neurons by activating at least two downstream targets, Rab5 (show RAB5A ELISA Kits), which is localized in both axons and dendrites, and Rab17 (show RAB17 ELISA Kits), which is localized in dendrites alone
Data reveal the affinity of Rabex-5 (show RABGEF1 ELISA Kits)/Rabaptin-5/Rab5 (show RAB5A ELISA Kits)-GTP (show AK3 ELISA Kits) interaction in the cell, which is quantitatively related to the Rabex-5 (show RABGEF1 ELISA Kits) concentration for the onset of the indirect positive feedback pathway.
Western blot analysis of the mouse brain showed reduced levels of calpastatin and rabaptin-5 and higher amount of neuronatin in PKU compared to the wild type.
Rabaptin-5 importantly contributes to mast cell IgE-dependent immunologic function by enhancing mast cell receptor surface stability.
human homolog is a member of a protein complex that regulates endosome fusion
, rab GTPase-binding effector protein 1
, renal carcinoma antigen NY-REN-17
, RAB5 effector protein
, rabaptin 5