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human homolog is a member of a protein complex that regulates endosome fusion. Additionally we are shipping and many more products for this protein.
Showing 10 out of 23 products:
Human Monoclonal RABEP1 Primary Antibody for IF, IP - ABIN968104
Shiba, Takatsu, Shin, Nakayama: Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain. in Journal of biochemistry 2002
Show all 3 references for ABIN968104
Human Polyclonal RABEP1 Primary Antibody for IHC, ELISA - ABIN1535243
Stenmark, Vitale, Ullrich, Zerial: Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion. in Cell 1996
The results contradict the model of feedback activation of Rab5 (show RAB5A Antibodies) and instead indicate that Rbpt5 is recruited by both Rabex5 (show RABGEF1 Antibodies) recognizing ubiquitylated cargo and by Rab4 (show RAB4A Antibodies) to activate Rab5 (show RAB5A Antibodies) in a feed-forward manner.
ITSN2L interacts with RABEP1 and stimulates its degradation in regulation of endocytosis.
The pleckstrin (show PLEK Antibodies) homology domain (PH) of PLD1 itself promotes degradation of HIF-1alpha (show HIF1A Antibodies), then accelerates EGFR (show EGFR Antibodies) endocytosis via upregulation of rabaptin-5 and suppresses tumor progression.
analysis of Rabex-5 (show RABGEF1 Antibodies) GEF (show SLC2A4RG Antibodies) activation by Rabaptin-5
The disruption of Rabaptin-5 Ser407 phosphorylation reduces persistent cell migration in 2D and alphavbeta3-dependent invasion.
Silencing of Rabaptin-5 induces down-regulation of recycling of K(V)10.1 channel in transfected cells and reduction of K(V)10.1 current density in cells natively expressing K(V)10.1, indicating a role of Rabaptin-5 in channel trafficking.
Breast cancer cell line studies showed that microRNA, miR (show MLXIP Antibodies)-373, was capable of promoting breast cancer invasion and metastasis via translational inhibition of TXNIP (show TXNIP Antibodies) and RABEP1 that were the direct target genes of miR (show MLXIP Antibodies)-373.
GGAs, a family of Arf (show CDKN2A Antibodies)-dependent clathrin adaptors involved in selection of TGN (show TG Antibodies) cargo, interact with the Rabaptin-5-Rabex-5 (show RABGEF1 Antibodies) complex, a Rab4 (show RAB4A Antibodies)/Rab5 (show RAB5A Antibodies) effector regulating endosome fusion
The authors determined that increased listeriolysin O-independent dissolution of vacuoles during RABEP1 knockdown required the Listeria monocytogenes broad-range phospholipase C (show PLC Antibodies) (PC-PLC (show HSPG2 Antibodies)).
novel protein complex composed of Rabep1, GGA1 (show GGA1 Antibodies) and Arl3 is responsible for the sorting and targeting of the polycystin 1 (show PKD1 Antibodies) andpolycystin 2 to the cilium.
The intracellular localization of Rabaptin-5gamma indicates that it is not involved in Rab5 (show RAB5A Antibodies)-driven events--rather, it functions in other membrane transport steps; role of alternative splicing in determination of functional activities of Rab (show HRB Antibodies) effector molecules
our results assign Rab5 (show RAB5A Antibodies) a key role in mediating mast cell secretory granule fusion during biogenesis
Rabex-5 (show RABGEF1 Antibodies) regulates neurite morphogenesis of hippocampal neurons by activating at least two downstream targets, Rab5 (show RAB5A Antibodies), which is localized in both axons and dendrites, and Rab17 (show RAB17 Antibodies), which is localized in dendrites alone
Data reveal the affinity of Rabex-5 (show RABGEF1 Antibodies)/Rabaptin-5/Rab5 (show RAB5A Antibodies)-GTP (show AK3 Antibodies) interaction in the cell, which is quantitatively related to the Rabex-5 (show RABGEF1 Antibodies) concentration for the onset of the indirect positive feedback pathway.
Western blot analysis of the mouse brain showed reduced levels of calpastatin and rabaptin-5 and higher amount of neuronatin in PKU compared to the wild type.
Rabaptin-5 importantly contributes to mast cell IgE-dependent immunologic function by enhancing mast cell receptor surface stability.
human homolog is a member of a protein complex that regulates endosome fusion
, rab GTPase-binding effector protein 1
, renal carcinoma antigen NY-REN-17
, RAB5 effector protein
, rabaptin 5