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Rac GTPase Activating Protein 1 Proteins (RACGAP1)

The protein encoded by RACGAP1 belongs to the GTPase-activating protein (GAP) family. Additionally we are shipping RACGAP1 Antibodies (119) and RACGAP1 Kits (18) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RACGAP1 29127 Q9H0H5
RACGAP1 26934 Q9WVM1
Rat RACGAP1 RACGAP1 315298  
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Top RACGAP1 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RACGAP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Rac GTPase Activating Protein 1 (RACGAP1) Interaction Partners

Human Rac GTPase Activating Protein 1 (RACGAP1) interaction partners

  1. RacGAP1 Is a Novel Downstream Effector of E2F7 (show E2F7 Proteins)-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell Carcinoma

  2. RACGAP1 expression levels in the nucleus and cytoplasm, determined by immunohistochemical staining, predict opposite clinical outcomes and that both could be independent prognostic markers for colorectal cancer.

  3. central spindle assembly and 2 Plk1-dependent phosphorylations are required to establish efficient binding of the Ect2 (show ECT2 Proteins) BRCT in early cytokinesis.

  4. RacGAP1 expression at the invasive front in gastric cancer was significantly correlated with factors reflecting tumor progression and poor prognosis.RACGAP1 gene expression in diffuse type gastric cancer was elevated.

  5. RacGAP1 mediated endothelial barrier function loss and melanoma transmigration in a focal adhesion-dependent manner.RacGAP1 activation mediates focal adhesion assembly and actin stress fiber formation.

  6. High RacGAP1 expression was an independent predictive marker for lymph node metastasis, recurrence and poor prognosis in colorectal cancer patients.

  7. HCV viral protein NS5B polymerase activity was significantly reduced by silencing RacGAP1 and, vice versa, was increased by overexpression of RacGAP1 in a cell-based reporter assay.

  8. We show that some are new substrates of the anaphase-promoting complex/cyclosome and validate KIFC1 (show KIFC1 Proteins) and RacGAP1/Cyk4 as two such targets involved respectively in timely mitotic spindle disassembly and cell spreading

  9. MgcRacGAP colocalizes with CGN and CGNL1 at TJs and forms a complex and interacts directly in vitro with CGN and CGNL1.

  10. High expression of RACGAP1 is associated with meningiomas.

Mouse (Murine) Rac GTPase Activating Protein 1 (RACGAP1) interaction partners

  1. Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse.

  2. APC (show APC Proteins)(CDH1 (show CDH1 Proteins)) targets MgcRacGAP for destruction in the late M phase.

  3. TLR4 (show TLR4 Proteins) signaling shapes B cell dynamics via MyD88 (show MYD88 Proteins)-dependent pathways and Rac (show AKT1 Proteins) GTPases.

  4. several Rho family small GTPases activate PI3K by an indirect cooperative positive feedback that required a combination of Rac (show AKT1 Proteins), CDC42 (show CDC42 Proteins), and RhoG small GTPase activities

  5. Rac regulates vascular endothelial growth factor stimulated motility

  6. These results indicate that MgcRacGAP regulates cytokinesis and cellular differentiation as a regulator of Rho family of GTPase and suggest that this process is controlled by some serine/threonine kinases.

  7. alpha5 is required for proliferation and polarity of basal epithelial cells; the interaction between laminin-10/11-integrin alpha6beta4 and the PI3-kinase (show PIK3CA Proteins)-Cdc42 (show CDC42 Proteins)/Rac (show AKT1 Proteins) pathways may play a role in determining the size and shape of tooth germ

  8. Gab2 (show GAB2 Proteins) via Shp-2 (show PTPN11 Proteins) is critical for transmitting signals from Kit Tyr (show TYR Proteins)(567) to activate the Rac (show AKT1 Proteins)/JNK (show MAPK8 Proteins) pathway controlling mast cell proliferation

  9. Data demonstrate that normal cytokinesis in B lymphocytes requires the GAP and NH2 terminal domains but not GAP activity of mgcRacGAP.

  10. Rac (show AKT1 Proteins) became activated within 2 min after peripheral membrane extensions adhered to new ECM (show MMRN1 Proteins) islands, and this activation wave propagated outward in an oriented manner as the cells spread from island to island

RACGAP1 Protein Profile

Protein Summary

The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with RACGAP1

  • Rac GTPase activating protein 1 (racgap1)
  • Rac GTPase activating protein 1 (racgap1.2)
  • Rac GTPase activating protein 1 (RACGAP1)
  • Rac GTPase activating protein 1 (Racgap1)
  • Rac GTPase-activating protein 1 (Racgap1)
  • Rac GTPase-activating protein 1 (racgap1)
  • AI227039 protein
  • AI327394 protein
  • Band25 protein
  • cyk-4 protein
  • CYK4 protein
  • gtl11 protein
  • GTPase protein
  • HsCYK-4 protein
  • ID-GAP protein
  • MGC121578 protein
  • MgcRacGAP protein
  • mKIAA1478 protein
  • RACGAP1 protein
  • wu:fb92c08 protein
  • zgc:77839 protein

Protein level used designations for RACGAP1

Rac GTPase activating protein 1 , rac GTPase-activating protein 1-like , GTPase activating protein , male germ cell RacGap , protein CYK4 homolg , protein CYK4 homolog , rac GTPase-activating protein 1 , Rac GTPase-activating protein 1

GENE ID SPECIES
407917 Xenopus (Silurana) tropicalis
445828 Xenopus laevis
451887 Pan troglodytes
733574 Xenopus (Silurana) tropicalis
100059818 Equus caballus
100453002 Pongo abelii
100473385 Ailuropoda melanoleuca
100542045 Meleagris gallopavo
100558921 Anolis carolinensis
100595184 Nomascus leucogenys
29127 Homo sapiens
431862 Xenopus laevis
486549 Canis lupus familiaris
514618 Bos taurus
100517651 Sus scrofa
426884 Gallus gallus
100354099 Oryctolagus cuniculus
100721177 Cavia porcellus
26934 Mus musculus
315298 Rattus norvegicus
323197 Danio rerio
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