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Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. Additionally we are shipping Radixin Antibodies (108) and Radixin Proteins (4) and many more products for this protein.
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Phospho-Ezrin/Radixin/Moesin (ERM (show MSN ELISA Kits)) inhibit cell adhesion, and therefore, dephosphorylation of ERM proteins is essential for cell adhesion.Phospho-ERM induce formation and/or maintenance of spherical cell shape.
These studies identify Akt2 as a critical kinase that regulates radixin phosphorylation and leads to Mrp-2 translocation and function.
Intracellular sphingosine kinase 2 (show SPHK2 ELISA Kits)-derived sphingosine-1-phosphate mediates epidermal growth factor (show EGF ELISA Kits)-induced ezrin-radixin-moesin (show MSN ELISA Kits) phosphorylation and cancer cell invasion.
High Radixin expression is associated with glioblastoma.
Ezrin (show EZR ELISA Kits), radixin and moesin (show MSN ELISA Kits) are unlikely targets for autoantibodies in demyelinating neuropathies.
Data show that silencing ezrin-radixin-moesin (ERM (show MSN ELISA Kits)) protein expression ablates deleted in colorectal carcinoma (show DCC ELISA Kits) protein (DCC (show DCC ELISA Kits))-protein kinase A (PKA) interaction and specifically blocks netrin-induced PKA activity and phosphorylation.
These data suggest an association between RDX polymorphisms and the clinical features of RA patients, particularly the ESR (show ESR1 ELISA Kits)
Radixin was identified as a target gene of miR (show MLXIP ELISA Kits)-196a/-196b. Elevated miR (show MLXIP ELISA Kits)-196a/-196b expression in GC cells led to reduced radixin protein levels and vice versa.
This study finding have implications concerning the importance of concomitant radixin upregulation in tumor progression and poor prognosis of patients with gliomas.
VIP (show Vip ELISA Kits) regulates CFTR (show CFTR ELISA Kits) membrane expression and function in Calu (show CALU ELISA Kits)-3 cells by increasing its interaction with NHERF1 (show SLC9A3R1 ELISA Kits) and P-ERM in a VPAC1 (show VIPR1 ELISA Kits)- and PKCepsilon (show PRKCE ELISA Kits)-dependent manner.
These results indicate that radixin plays an important role in regulating P-glycoprotein localization and P-glycoprotein functional activity at the intestinal membrane.
The specific location of radixin-positive cells in the peri (show POSTN ELISA Kits)-infarct region and in microglia suggests a role for radixin in microglial activation after stroke.
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.
the extracellular matrix molecule VN and its neuronal receptor TLCN (show ICAM5 ELISA Kits) play a pivotal role in the phosphorylation of ezrin/radixin/moesin (show MSN ELISA Kits) proteins and the formation of phagocytic cup-like structures on neuronal dendrites
Ezrin/radixin/moesin (show MSN ELISA Kits) are required for the purinergic P2X7 receptor (P2X7R (show P2RX7 ELISA Kits))-dependent processing of the amyloid precursor protein (show APP ELISA Kits).
The ERM (ezrin, radixin, moesin) proteins are novel scaffolds at the level of SOS activity control, which is relevant for both normal Ras function and dysfunction known to occur in several human cancers.
Ezrin-radixin-moesin (ERM (show MSN ELISA Kits)) proteins are induced in activated microglia/macrophages, whereas ERM molecules are only marginally expressed in quiescent microglia in the normal brain.
Ezrin (show EZR ELISA Kits), radixin, and moesin (show MSN ELISA Kits) are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability.
Results show that while CD43 binding to ezrin-radixin-moesin proteins is crucial for S76 phosphorylation, CD43 movement and regulation of T-cell migration can occur through an ERM-independent, phosphorylation-dependent mechanism.
Radixin inactivation causes hyperbilirubinemia (likely due to a defect in the localization Multidrug resistance protein 2 (show ABCC2 ELISA Kits) in the bile canalicular membranes) and deafness due to progressive degeneration of cochlear stereocilia. (Review)
Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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