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Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds.
Our data collectively demonstrate that TGM3 can be a candidate tumor suppressor that is able to induce esophageal cancer cell proliferation and migration
mRNA expression of transglutaminase 1 (show TGM1 Antibodies) and transglutaminase 3 was significantly decreased in patients with chronic periodontitis compared with a healthy control group.
Transglutaminase 3 present in the IgA aggregates in dermatitis herpetiformis skin is enzymatically active and binds soluble fibrinogen.
New basal cell carcinoma susceptibility loci were identified at TGM3 (rs214782) and RGS22 (show RGS22 Antibodies)(rs7006527).
IgA-anti-TG1 antibodies were found in 2% and IgA-anti-TG3 antibodies in 3% of patients with active atopic dermatitis (AD). Two out of the 5 patients with AD and concomitant celiac disease had IgA-anti-TG1 and IgA-anti-TG2 (show TGM2 Antibodies) antibodies.
TGM3, a candidate tumor suppressor, contributes to the carcinogenesis and development of human head and neck cancer.
Genetic variation in the epidermal transglutaminase genes is not associated with atopic dermatitis.
The low expression of TGM3 may contribute to the carcinogenesis and development of laryngeal carcinoma.
TGM3 in immunoglobulin A (IgA) and TGM3 immune complexes is responsible for cross-linking and tight binding of IgA to connective tissue in the dermis and explains the IgA deposits in dermatitis herpetiformis skin long after signs of disease are resolved.
findings lend credence to the notion that TG3 and TG6 are involved in the gluten-induced autoimmune responses of dermatitis herpetiformis and gluten ataxia (show USP14 Antibodies)
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle.
E polypeptide, protein-glutamine-gamma-glutamyltransferase
, TGase E
, protein-glutamine gamma-glutamyltransferase E
, transglutaminase E