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anti-Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) Antibodies

binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner. Additionally we are shipping Rap Guanine Nucleotide Exchange Factor (GEF) 3 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RAPGEF3 10411 O95398
RAPGEF3 223864 Q8VCC8
RAPGEF3 59326 Q9Z1C8
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Top anti-Rap Guanine Nucleotide Exchange Factor (GEF) 3 Antibodies at antibodies-online.com

Showing 10 out of 63 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-RAPGEF3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: HCT15 cell lysate WB Suggested Anti-RAPGEF3  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: HCT15 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-RAPGEF3 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: COLO205 cell lysate WB Suggested Anti-RAPGEF3  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: COLO205 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemistry of EPAC1 in rat brain tissue with EPAC1 Antibody at 2.5 µg/ml. Western blot analysis of EPAC1 in rat skeletal muscle tissue lysate with EPAC1 Antibody  at 1 µg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Cow Rabbit Un-conjugated IC, IF, WB Immunofluorescent analysis of EPAC1 staining in A549 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of EPAC1 expression in A549 (A), SP2/0 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Antigen: 0.2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Goat-Anti-Rabbit IgG at 1: 5000;  TMB staining;  Read the data in MicroplateReader by 450 100 μL Log in to see 3 to 7 Days
$269.50
Details

RAPGEF3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Rap Guanine Nucleotide Exchange Factor (GEF) 3 Antibodies

  1. Human Polyclonal RAPGEF3 Primary Antibody for EIA, WB - ABIN492970 : Kerr, Costa-Pereira, Lillemeier, Strobl: Of JAKs, STATs, blind watchmakers, jeeps and trains. in FEBS letters 2003 (PubMed)
    Show all 6 references for ABIN492970

  2. Human Polyclonal RAPGEF3 Primary Antibody for EIA, WB - ABIN492968 : Magiera, Gupta, Rundell, Satish, Ernens, Yarwood: Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A. in The Biochemical journal 2004 (PubMed)
    Show all 6 references for ABIN492968

  3. Human Polyclonal RAPGEF3 Primary Antibody for ELISA, WB - ABIN1451502 : Scherer, Muzny, Buhay, Chen, Cree, Ding, Dugan-Rocha, Gill, Gunaratne, Harris, Hawes, Hernandez, Hodgson, Hume, Jackson, Khan, Kovar-Smith, Lewis, Lozado, Metzker, Milosavljevic, Miner, Montgomery et al.: The finished DNA sequence of human chromosome 12. ... in Nature 2006 (PubMed)

More Antibodies against Rap Guanine Nucleotide Exchange Factor (GEF) 3 Interaction Partners

Cow (Bovine) Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) interaction partners

  1. prostacyclin regulates bone growth via the Epac/Rap1 pathway

Xenopus laevis Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) interaction partners

  1. cAMP binds Xepac protein enabling it to activate the Ca2 (show CA2 Antibodies)+ pathway, which is necessary to start and maintain X. laevis vitellogenin (show VTG Antibodies) uptake.

Human Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) interaction partners

  1. EPAC activation consistently reverses clinical and experimental impairment of neutrophil phagocytosis. EPAC signals through Rap-1 (show RABGEF1 Antibodies) and bypasses RhoA (show RHOA Antibodies). EPAC activation represents a novel potential means by which to reverse impaired neutrophil phagocytosis.

  2. The cAMP exerted divergent effects on proliferation and promoted cell adhesion of different neuroendocrine cell types, these effects being mediated by both Epac and PKA and involving the same effector GTPase Rap1.

  3. Impaired microtubule dynamics, due to reduced EPAC1 signaling, links CFTR (show CFTR Antibodies) function to cystic fibrosis (show S100A8 Antibodies) cellular events.

  4. Identified a conserved nuclear pore localisation signal (NPLS; amino acids 764-838 of EPAC1) in the catalytic domains of the cAMP-sensors, EPAC1 and EPAC2A. EPAC1 and EPAC2 (show RAPGEF4 Antibodies), display distinct subcellular distributions.

  5. Thyroid carcinoma cell lines showed no or very weak EPAC1 expression and exhibited no growth-promoting effect after EPAC stimulation.

  6. findings, coupled with the development of EPAC specific small molecule modulators, validate EPAC1 as a promising target for therapeutic interventions

  7. association of ezrin (show EZR Antibodies) with the actin cytoskeleton and phosphorylation on Thr567 are required, but not sufficient, for PKA and EPAC1 to synergistically promote cell spreading following elevations in intracellular cAMP.

  8. These results demonstrate that glucagon (show GCG Antibodies) increases hepatic FGF21 (show FGF21 Antibodies) secretion via a posttranscriptional mechanism and provide evidence that both the PKA branch and EPAC branch of the cAMP pathway play a role in mediating this effect.

  9. Sequestration of sperm Rab27 (show RAB27A Antibodies) prevents subsequent cAMP/Epac-dependent calcium mobilization from the acrosome.

  10. Our data may suggest that the downregulation of pulmonary Epac1 expression in COPD (show ARCN1 Antibodies) patients is related to the upregulation of miRNA-7

Mouse (Murine) Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) interaction partners

  1. GRK2 inhibits Epac1-to-Rap1 signaling by phosphorylation of Epac1 at Ser-108 in the Disheveled/Egl-10/pleckstrin domain, inhibiting agonist-induced Epac1 translocation to the plasma membrane, reducing Rap1 activation.

  2. DPP4i restores cardiac remodeling and apoptosis caused by the pathological decline in circulating GLP-1 in response to pressure overload. EPAC1 is essential for cardiomyocyte survival via the cAMP/Rap1 activation independently of PKA.

  3. Epac2 (show RAPGEF4 Antibodies), but not Epac1 has a role in decreasing severity of ischemic retinopathy after retinal ischemia/reperfusion injury

  4. Epac1 deficiency attenuates neointima formation through, at least in part, inhibition of SMC (show DYM Antibodies) migration, in which a decrease in Ca(2 (show CA2 Antibodies)+) influx and a suppression of cofilin (show CFL1 Antibodies)-mediated lamellipodia formation occur.

  5. PDE4 (show PDE4A Antibodies) inhibition reduces neointima formation and inhibits VCAM-1 (show VCAM1 Antibodies) expression and histone methylation in an Epac-dependent manner.

  6. Epac1 deletion protected against beta-AR-induced cardiac remodelling and prevented the induction of autophagy.

  7. Epac1 induces beta2-AR-mediated masseter muscle hypertrophy without influencing slow-to-fast MHC isoform transition, probably via activation of Akt (show AKT1 Antibodies) and its downstream molecules and increase of CaMKII (show CAMK2G Antibodies)-mediated HDAC4 (show HDAC5 Antibodies) phosphorylation.

  8. these data show that Treg degrade ATP to adenosine via CD39, attracting DC by activating Epac1-Rap1-dependent pathways.

  9. EPAC1 was found to facilitate metastasis of pancreatic ductal carcinoma.

  10. prostacyclin regulates bone growth via the Epac/Rap1 pathway

Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) Antigen Profile

Protein Summary

binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner

Gene names and symbols associated with RAPGEF3

  • Rap guanine nucleotide exchange factor (GEF) 3 (RAPGEF3) antibody
  • Rap guanine nucleotide exchange factor (GEF) 3 (rapgef3) antibody
  • Rap guanine nucleotide exchange factor (GEF) 3 (Rapgef3) antibody
  • 2310016P22Rik antibody
  • 9330170P05Rik antibody
  • bcm910 antibody
  • CAMP-GEFI antibody
  • Epac antibody
  • Epac1 antibody
  • HSU79275 antibody
  • RAPGEF3 antibody
  • si:dkey-27m20.2 antibody

Protein level used designations for RAPGEF3

Rap guanine nucleotide exchange factor (GEF) 3 , RAP guanine-nucleotide-exchange factor 3 , exchange protein directly activated by cAMP 1 , rap guanine nucleotide exchange factor 3 , Rap1 guanine-nucleotide exchange factor , rap guanine nucleotide exchange factor 3-like , 9330170P05Rik , EPAC 1 , Rap1 guanine-nucleotide-exchange factor directly activated by cAMP , cAMP-regulated guanine nucleotide exchange factor I , exchange factor directly activated by cAMP 1 , cAMP-GEFI , cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI) , epac 1

GENE ID SPECIES
426888 Gallus gallus
467198 Pan troglodytes
486591 Canis lupus familiaris
535383 Bos taurus
703967 Macaca mulatta
733186 Xenopus laevis
100174087 Pongo abelii
100320646 Danio rerio
100399583 Callithrix jacchus
100473947 Ailuropoda melanoleuca
100560594 Anolis carolinensis
10411 Homo sapiens
223864 Mus musculus
59326 Rattus norvegicus
Selected quality suppliers for anti-Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3) Antibodies
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