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anti-Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4) Antibodies

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Additionally we are shipping RAPGEF4 Proteins (6) and RAPGEF4 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RAPGEF4 11069 Q8WZA2
RAPGEF4 56508 Q9EQZ6
RAPGEF4 252857  
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Top anti-RAPGEF4 Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Immunohistochemistry of EPAC3 in mouse liver tissue with EPAC3 Antibody at 2.5 µg/ml. Western blot analysis of EPAC2 in rat liver tissue lysate with EPAC2 Antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 6 to 8 Days
$456.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-Epac2 Polyclonal Antibody, Unconjugated (ABIN2173847) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 14 to 21 Days
$269.50
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged RAPGEF4 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 3 to 7 Days
$357.50
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 3 to 7 Days
$357.50
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 3 to 7 Days
$357.50
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 3 to 7 Days
$357.50
Details
Human Rabbit Biotin IHC (p)   100 μL Log in to see 3 to 7 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 3 to 7 Days
$357.50
Details

RAPGEF4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-RAPGEF4 Antibodies

  1. Human Polyclonal RAPGEF4 Primary Antibody for EIA, WB - ABIN492972 : Kerr, Costa-Pereira, Lillemeier, Strobl: Of JAKs, STATs, blind watchmakers, jeeps and trains. in FEBS letters 2003 (PubMed)
    Show all 6 references for ABIN492972

  2. Human Polyclonal RAPGEF4 Primary Antibody for IHC (p), WB - ABIN1450105 : Holz, Kang, Harbeck, Roe, Chepurny: Cell physiology of cAMP sensor Epac. in The Journal of physiology 2006 (PubMed)
    Show all 3 references for ABIN1450105

More Antibodies against RAPGEF4 Interaction Partners

Human Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4) interaction partners

  1. Data show that Epac2 is activated by cAMP and changes its structure. It is involved in cAMP-mediated signal transduction through activation of the Ras-like small GTPase (show RAP2B Antibodies) and is expressed mainly in brain, neuroendocrine and endocrine tissues. [review]

  2. Identified a conserved nuclear pore localisation signal (NPLS; amino acids 764-838 of EPAC1 (show RAPGEF3 Antibodies)) in the catalytic domains of the cAMP-sensors, EPAC1 (show RAPGEF3 Antibodies) and EPAC2A. EPAC1 (show RAPGEF3 Antibodies) and EPAC2, display distinct subcellular distributions.

  3. CALR (show CALR Antibodies) regulated by EPAC2 in endometrial glandular epithelial cells is critical for the expression of LIF (show LIF Antibodies) and PTGS2 (show PTGS2 Antibodies)-mediated production of PGE2 through cAMP signaling.

  4. Follow-up replication analyses in up to an additional 21,345 participants identified three new fasting plasma glucose loci reaching genome-wide significance in or near PDK1 (show PDK1 Antibodies)-RAPGEF4, KANK1 (show ANKRD15 Antibodies), and IGF1R (show IGF1R Antibodies).

  5. EPAC1 and EPAC2 are critical signaling intermediates in osteoclast differentiation that permit RANKL-stimulated NFkB nuclear translocation and actin rearrangements

  6. data show the expression of E (show RAPGEF3 Antibodies)PAC is blunted in HPRT-deficient neuron-like cell lines (show HPRT1 Antibodies)and fibroblast cells from Lesch-Nyhan syndrome (LNS) (show RAPGEF3 Antibodies)patie (show RABGEF1 Antibodies)nts; propose that the alterations in (show HPRT1 Antibodies)EPAC/RAP1 signaling and cell migration in HPRT deficiency are crucial for neuro-developmental events that may contribute to neurological dysfunctions in LNS

  7. EPAC2-mediated CRT (show SLC6A8 Antibodies) expression is essential for the functional and morphological differentiation of endometrial stromal cells into decidual cells

  8. Cigarette smoke extract decreased Epac1 (show RAPGEF3 Antibodies) expression, but did not affect Epac2 and PKA expression.

  9. Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry

  10. An important time-limited role is identified for hippocampal Epac2 signaling in cognition, opening new avenues to investigate the molecular mechanisms underlying memory retrieval.

Mouse (Murine) Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4) interaction partners

  1. Epac2, but not Epac1 (show RAPGEF3 Antibodies) has a role in decreasing severity of ischemic retinopathy after retinal ischemia/reperfusion injury

  2. cAMP-GEF (show ARHGEF2 Antibodies) II plays a key role in hippocampal functions including behavioral flexibility.

  3. data suggest that cAMP elevation uses an Epac2-dependent pathway to promote transmitter release, and that Epac2 is required to maintain the readily releasable pool at Mossy Fiber synapses in the hippocampus.

  4. Epac1 (show RAPGEF3 Antibodies) primarily is capable of inhibiting remodeling processes, whereas Epac2 primarily increases inflammatory processes in vivo

  5. EPAC1 and EPAC2 are critical signaling intermediates in osteoclast differentiation that permit RANKL-stimulated NFkB nuclear translocation and actin rearrangements

  6. data show the expression EPAC (show RAPGEF3 Antibodies) is altered in the cortex, striatum and midbrain of HPRT (show HPRT1 Antibodies) knockout mouse; propose that the alterations in EPAC (show RAPGEF3 Antibodies)/RAP1 (show TERF2IP Antibodies) signaling and cell migration in HPRT (show HPRT1 Antibodies) deficiency are crucial for neuro-developmental events that may contribute to neurological dysfunctions in Lesch-Nyhan syndrome

  7. DNA methylation (show HELLS Antibodies) of alternative promoters directs tissue specific expression of Epac2 isoforms.

  8. Epac2 localization is dynamically controlled by cAMP as well as by Ca(2+)-mediated activation of Ras.

  9. EPAC2A is required for potentiating the early dynamic increase in islet calcium levels after glucose stimulation, which is reflected in potentiated first-phase insulin (show INS Antibodies) secretion.

  10. there is a gut (show GUSB Antibodies)-heart GLP-1R (show GLP1R Antibodies)-dependent and ANP (show NPPA Antibodies)-dependent axis that regulates blood pressure and involves Epac2

RAPGEF4 Antigen Profile

Protein Summary

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity).

Gene names and symbols associated with RAPGEF4

  • Rap guanine nucleotide exchange factor (GEF) 4 (RAPGEF4) antibody
  • Rap guanine nucleotide exchange factor (GEF) 4 (LOC100348394) antibody
  • rap guanine nucleotide exchange factor 4 (PTRG_05798) antibody
  • Rap guanine nucleotide exchange factor (GEF) 4 (Rapgef4) antibody
  • 1300003D15Rik antibody
  • 5730402K07Rik antibody
  • 6330581N18Rik antibody
  • CAMP-GEFII antibody
  • CAMPS antibody
  • Cgef2 antibody
  • Epac-2 antibody
  • EPAC 2 antibody
  • Epac2 antibody
  • mKIAA4040 antibody
  • Nbla00496 antibody
  • RAPGEF4 antibody

Protein level used designations for RAPGEF4

Rap guanine nucleotide exchange factor (GEF) 4 , rap guanine nucleotide exchange factor 4 , rap guanine nucleotide exchange factor 4-like , EPAC 2 , RAP guanine-nucleotide-exchange factor (GEF) 4 , cAMP-regulated guanine nucleotide exchange factor II , exchange factor directly activated by cAMP 2 , exchange protein directly activated by cAMP 2 , putative protein product of Nbla00496 , cAMP-GEFII , cAMP-dependent Rap1 guanine-nucleotide exchange factor , cAMP-regulated guanine nucleotide exchange factor IIB , epac 2

GENE ID SPECIES
459744 Pan troglodytes
429022 Gallus gallus
488402 Canis lupus familiaris
537312 Bos taurus
579050 Strongylocentrotus purpuratus
698148 Macaca mulatta
100025283 Monodelphis domestica
100064121 Equus caballus
100084234 Ornithorhynchus anatinus
100174040 Pongo abelii
100348394 Oryctolagus cuniculus
100401754 Callithrix jacchus
100480097 Ailuropoda melanoleuca
100551109 Meleagris gallopavo
100602878 Nomascus leucogenys
6344052 Pyrenophora tritici-repentis Pt-1C-BFP
11069 Homo sapiens
56508 Mus musculus
252857 Rattus norvegicus
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