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Rap Guanine Nucleotide Exchange Factor (GEF) 4 Proteins (RAPGEF4)

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Additionally we are shipping RAPGEF4 Antibodies (36) and RAPGEF4 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RAPGEF4 11069 Q8WZA2
RAPGEF4 56508 Q9EQZ6
RAPGEF4 252857  
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Top RAPGEF4 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RAPGEF4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4) Interaction Partners

Human Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4) interaction partners

  1. Data show that Epac2 is activated by cAMP and changes its structure. It is involved in cAMP-mediated signal transduction through activation of the Ras-like small GTPase (show RAP2B Proteins) and is expressed mainly in brain, neuroendocrine and endocrine tissues. [review]

  2. Identified a conserved nuclear pore localisation signal (NPLS; amino acids 764-838 of EPAC1 (show RAPGEF3 Proteins)) in the catalytic domains of the cAMP-sensors, EPAC1 (show RAPGEF3 Proteins) and EPAC2A. EPAC1 (show RAPGEF3 Proteins) and EPAC2, display distinct subcellular distributions.

  3. CALR (show CALR Proteins) regulated by EPAC2 in endometrial glandular epithelial cells is critical for the expression of LIF (show LIF Proteins) and PTGS2 (show PTGS2 Proteins)-mediated production of PGE2 through cAMP signaling.

  4. Follow-up replication analyses in up to an additional 21,345 participants identified three new fasting plasma glucose loci reaching genome-wide significance in or near PDK1 (show PDK1 Proteins)-RAPGEF4, KANK1, and IGF1R (show IGF1R Proteins).

  5. EPAC1 and EPAC2 are critical signaling intermediates in osteoclast differentiation that permit RANKL-stimulated NFkB nuclear translocation and actin rearrangements

  6. data show the expression of E (show RAPGEF3 Proteins)PAC is blunted in HPRT-deficient neuron-like cell lines (show HPRT1 Proteins)and fibroblast cells from Lesch-Nyhan syndrome (LNS) (show RAPGEF3 Proteins)patie (show RABGEF1 Proteins)nts; propose that the alterations in (show HPRT1 Proteins)EPAC/RAP1 signaling and cell migration in HPRT deficiency are crucial for neuro-developmental events that may contribute to neurological dysfunctions in LNS

  7. EPAC2-mediated CRT (show SLC6A8 Proteins) expression is essential for the functional and morphological differentiation of endometrial stromal cells into decidual cells

  8. Cigarette smoke extract decreased Epac1 (show RAPGEF3 Proteins) expression, but did not affect Epac2 and PKA expression.

  9. Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry

  10. An important time-limited role is identified for hippocampal Epac2 signaling in cognition, opening new avenues to investigate the molecular mechanisms underlying memory retrieval.

Mouse (Murine) Rap Guanine Nucleotide Exchange Factor (GEF) 4 (RAPGEF4) interaction partners

  1. Epac2, but not Epac1 (show RAPGEF3 Proteins) has a role in decreasing severity of ischemic retinopathy after retinal ischemia/reperfusion injury

  2. cAMP-GEF (show ARHGEF2 Proteins) II plays a key role in hippocampal functions including behavioral flexibility.

  3. data suggest that cAMP elevation uses an Epac2-dependent pathway to promote transmitter release, and that Epac2 is required to maintain the readily releasable pool at Mossy Fiber synapses in the hippocampus.

  4. Epac1 (show RAPGEF3 Proteins) primarily is capable of inhibiting remodeling processes, whereas Epac2 primarily increases inflammatory processes in vivo

  5. EPAC1 and EPAC2 are critical signaling intermediates in osteoclast differentiation that permit RANKL-stimulated NFkB nuclear translocation and actin rearrangements

  6. data show the expression EPAC (show RAPGEF3 Proteins) is altered in the cortex, striatum and midbrain of HPRT (show HPRT1 Proteins) knockout mouse; propose that the alterations in EPAC (show RAPGEF3 Proteins)/RAP1 (show TERF2IP Proteins) signaling and cell migration in HPRT (show HPRT1 Proteins) deficiency are crucial for neuro-developmental events that may contribute to neurological dysfunctions in Lesch-Nyhan syndrome

  7. DNA methylation (show HELLS Proteins) of alternative promoters directs tissue specific expression of Epac2 isoforms.

  8. Epac2 localization is dynamically controlled by cAMP as well as by Ca(2+)-mediated activation of Ras.

  9. EPAC2A is required for potentiating the early dynamic increase in islet calcium levels after glucose stimulation, which is reflected in potentiated first-phase insulin (show INS Proteins) secretion.

  10. there is a gut (show GUSB Proteins)-heart GLP-1R (show GLP1R Proteins)-dependent and ANP (show NPPA Proteins)-dependent axis that regulates blood pressure and involves Epac2

RAPGEF4 Protein Profile

Protein Summary

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA- independent exocytosis through interaction with RIMS2 (By similarity).

Gene names and symbols associated with RAPGEF4

  • Rap guanine nucleotide exchange factor (GEF) 4 (RAPGEF4)
  • Rap guanine nucleotide exchange factor (GEF) 4 (LOC100348394)
  • rap guanine nucleotide exchange factor 4 (PTRG_05798)
  • Rap guanine nucleotide exchange factor (GEF) 4 (Rapgef4)
  • 1300003D15Rik protein
  • 5730402K07Rik protein
  • 6330581N18Rik protein
  • CAMP-GEFII protein
  • CAMPS protein
  • Cgef2 protein
  • Epac-2 protein
  • EPAC 2 protein
  • Epac2 protein
  • mKIAA4040 protein
  • Nbla00496 protein
  • RAPGEF4 protein

Protein level used designations for RAPGEF4

Rap guanine nucleotide exchange factor (GEF) 4 , rap guanine nucleotide exchange factor 4 , rap guanine nucleotide exchange factor 4-like , EPAC 2 , RAP guanine-nucleotide-exchange factor (GEF) 4 , cAMP-regulated guanine nucleotide exchange factor II , exchange factor directly activated by cAMP 2 , exchange protein directly activated by cAMP 2 , putative protein product of Nbla00496 , cAMP-GEFII , cAMP-dependent Rap1 guanine-nucleotide exchange factor , cAMP-regulated guanine nucleotide exchange factor IIB , epac 2

GENE ID SPECIES
459744 Pan troglodytes
429022 Gallus gallus
488402 Canis lupus familiaris
537312 Bos taurus
579050 Strongylocentrotus purpuratus
698148 Macaca mulatta
100025283 Monodelphis domestica
100064121 Equus caballus
100084234 Ornithorhynchus anatinus
100174040 Pongo abelii
100348394 Oryctolagus cuniculus
100401754 Callithrix jacchus
100480097 Ailuropoda melanoleuca
100551109 Meleagris gallopavo
100602878 Nomascus leucogenys
6344052 Pyrenophora tritici-repentis Pt-1C-BFP
11069 Homo sapiens
56508 Mus musculus
252857 Rattus norvegicus
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