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Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Additionally we are shipping Rap Guanine Nucleotide Exchange Factor (GEF) 6 Proteins (3) and many more products for this protein.
Showing 10 out of 38 products:
Human Monoclonal RAPGEF6 Primary Antibody for IF, IHC (p) - ABIN565663
Okada, Miyake, Yamaguchi, Chiba, Maeta, Bilasy, Edamatsu, Kataoka, Fujisawa: Critical function of RA-GEF-2/Rapgef6, a guanine nucleotide exchange factor for Rap1, in mouse spermatogenesis. in Biochemical and biophysical research communications 2014
local accumulation of PDZGEF at the apical membrane during establishment of epithelial polarity is mediated by electrostatic interactions between positively charged side chains in the PDZ domain (show INADL Antibodies) and negatively charged phosphatidic acid.
BAG3 (show BAG3 Antibodies) overexpression increases cell adhesion in Cos7 cells, but not in PDZGEF2 gene knockdown cells indicating that PDZGEF2 is a critical partner for BAG3 (show BAG3 Antibodies) in regulating cell adhesion
the second PDZ domain (show INADL Antibodies) from human phosphatase hPTP1E (show PTPN13 Antibodies) in complex with a C-terminal peptide from the guanine nucleotide exchange factor (show RASGRF1 Antibodies) RA-GEF-2 has been determined
haplotypes underlying the SPEC2 (show CDC42SE2 Antibodies)/PDZ-GEF2/acyl-CoA synthetase long-chain family member 6 (show ACSL6 Antibodies) region are associated with schizophrenia
PDZ-GEF2 plays a critical role in the maturation of adherens junctions.
When males and females were analysed separately, SNP4 (rs31251) in PDZ-GEF2 is associated with schizophrenia in females in Han Chinese.
JAM-A (show F11R Antibodies) dimerization facilitates formation of a complex with Afadin (show MLLT4 Antibodies) and PDZ-GEF2 that activates Rap1A (show RAP1A Antibodies), which regulates beta1 integrin levels and cell migration.
Rapgef6 deletion mice were impaired in hippocampal and amygdalar function and had reduced spine density and primary dendrite number in pyramidal neurons of the CA3 (show CA3 Antibodies) hippocampal region.
Data indicate that the testes of RA-GEF-2(-)knockout male mice were significantly smaller than those of wild-type mice and were markedly atrophied as well as hypospermatogenic.
These findings proved a crucial role of the cross-talk between two Ras-family GTPases M-Ras (show MRAS Antibodies) and Rap1 (show TERF2IP Antibodies), mediated by RA-GEF-2, in adhesion signaling.
Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.
Rap guanine nucleotide exchange factor (GEF) 6
, PDZ domain-containing guanine nucleotide exchange factor I
, rap guanine nucleotide exchange factor 6-like
, PDZ domain containing guanine nucleotide exchange factor (GEF) 2
, PDZ domain-containing guanine nucleotide exchange factor 2
, rap guanine nucleotide exchange factor 6
, PDZ domain containing guanine nucleotide exchange factor(GEF)1
, rap guanine nucleotide exchange factor 2