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Rap Guanine Nucleotide Exchange Factor (GEF) 6 Proteins (RAPGEF6)

Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Additionally we are shipping Rap Guanine Nucleotide Exchange Factor (GEF) 6 Antibodies (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RAPGEF6 51735 Q8TEU7
Rat RAPGEF6 RAPGEF6 303141  
Mouse RAPGEF6 RAPGEF6 192786  
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Top Rap Guanine Nucleotide Exchange Factor (GEF) 6 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RAPGEF6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

More Proteins for Rap Guanine Nucleotide Exchange Factor (GEF) 6 (RAPGEF6) Interaction Partners

Human Rap Guanine Nucleotide Exchange Factor (GEF) 6 (RAPGEF6) interaction partners

  1. local accumulation of PDZGEF at the apical membrane during establishment of epithelial polarity is mediated by electrostatic interactions between positively charged side chains in the PDZ domain and negatively charged phosphatidic acid.

  2. BAG3 (show BAG3 Proteins) overexpression increases cell adhesion in Cos7 cells, but not in PDZGEF2 gene knockdown cells indicating that PDZGEF2 is a critical partner for BAG3 (show BAG3 Proteins) in regulating cell adhesion

  3. the second PDZ domain from human phosphatase hPTP1E (show PTPN13 Proteins) in complex with a C-terminal peptide from the guanine nucleotide exchange factor (show RASGRF1 Proteins) RA-GEF-2 has been determined

  4. haplotypes underlying the SPEC2 (show CDC42SE2 Proteins)/PDZ-GEF2/acyl-CoA synthetase long-chain family member 6 (show ACSL6 Proteins) region are associated with schizophrenia

  5. PDZ-GEF2 plays a critical role in the maturation of adherens junctions.

  6. When males and females were analysed separately, SNP4 (rs31251) in PDZ-GEF2 is associated with schizophrenia in females in Han Chinese.

  7. JAM-A (show F11R Proteins) dimerization facilitates formation of a complex with Afadin and PDZ-GEF2 that activates Rap1A (show RAP1A Proteins), which regulates beta1 integrin levels and cell migration.

Mouse (Murine) Rap Guanine Nucleotide Exchange Factor (GEF) 6 (RAPGEF6) interaction partners

  1. Rapgef6 deletion mice were impaired in hippocampal and amygdalar function and had reduced spine density and primary dendrite number in pyramidal neurons of the CA3 (show CA3 Proteins) hippocampal region.

  2. Data indicate that the testes of RA-GEF-2(-)knockout male mice were significantly smaller than those of wild-type mice and were markedly atrophied as well as hypospermatogenic.

  3. These findings proved a crucial role of the cross-talk between two Ras-family GTPases M-Ras (show MRAS Proteins) and Rap1 (show TERF2IP Proteins), mediated by RA-GEF-2, in adhesion signaling.

Rap Guanine Nucleotide Exchange Factor (GEF) 6 (RAPGEF6) Protein Profile

Protein Summary

Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.

Gene names and symbols associated with RAPGEF6

  • Rap guanine nucleotide exchange factor (GEF) 6 (rapgef6)
  • Rap guanine nucleotide exchange factor (GEF) 6 (RAPGEF6)
  • Rap guanine nucleotide exchange factor (GEF) 6 (Rapgef6)
  • A530068K01 protein
  • AI844632 protein
  • BB085664 protein
  • C030018K18Rik protein
  • KIA001LB protein
  • mKIAA4052 protein
  • PDZ-GEF2 protein
  • Pdzgef2 protein
  • RA-GEF-2 protein
  • Ragef2 protein
  • RAPGEF6 protein
  • wu:fa12b02 protein

Protein level used designations for RAPGEF6

Rap guanine nucleotide exchange factor (GEF) 6 , PDZ domain-containing guanine nucleotide exchange factor I , rap guanine nucleotide exchange factor 6-like , PDZ domain containing guanine nucleotide exchange factor (GEF) 2 , PDZ domain-containing guanine nucleotide exchange factor 2 , rap guanine nucleotide exchange factor 6 , PDZ domain containing guanine nucleotide exchange factor(GEF)1 , rap guanine nucleotide exchange factor 2

GENE ID SPECIES
335032 Danio rerio
416322 Gallus gallus
481496 Canis lupus familiaris
706541 Macaca mulatta
733941 Xenopus (Silurana) tropicalis
743392 Pan troglodytes
789597 Bos taurus
100015023 Monodelphis domestica
100063392 Equus caballus
100386485 Callithrix jacchus
100482379 Ailuropoda melanoleuca
100521255 Sus scrofa
100553829 Anolis carolinensis
100591273 Nomascus leucogenys
51735 Homo sapiens
303141 Rattus norvegicus
192786 Mus musculus
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