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Ras Association (RalGDS/AF-6) Domain Family Member 1 Proteins (RASSF1)

RASSF1 encodes a protein similar to the RAS effector proteins. Additionally we are shipping Ras Association (RalGDS/AF-6) Domain Family Member 1 Antibodies (122) and Ras Association (RalGDS/AF-6) Domain Family Member 1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RASSF1 11186 Q9NS23
RASSF1 56289 Q99MK9
Rat RASSF1 RASSF1 363140  
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Top Ras Association (RalGDS/AF-6) Domain Family Member 1 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
Details

RASSF1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Top referenced Ras Association (RalGDS/AF-6) Domain Family Member 1 Proteins

  1. Human RASSF1 Protein expressed in Escherichia coli (E. coli) - ABIN1098704 : Burbee, Forgacs, Zöchbauer-Müller, Shivakumar, Fong, Gao, Randle, Kondo, Virmani, Bader, Sekido, Latif, Milchgrub, Toyooka, Gazdar, Lerman, Zabarovsky, White, Minna: Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. in Journal of the National Cancer Institute 2001 (PubMed)
    Show all 2 references for ABIN1098704

More Proteins for Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) Interaction Partners

Human Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) interaction partners

  1. Different genetic mechanisms seem to contribute to RASSF1 deregulation in this setting, but RASSF1 methylation does not seem to substantially affect RASSF1 isoforms expression.

  2. RASSF1C gene is not involved in Clear-cell renal cell carcinoma (show MOK Proteins) (ccRCC)progression and we propose that the measurements of RASSF1A mRNA levels in paired tumor-normal kidney tissue could serve as a new prognostic factor in ccRCC

  3. Distinct RASSF1 isoforms have opposing functions, which provide a biomarker for YAP1 (show YAP1 Proteins) activation and explain correlations of RASSF1 methylation with advanced invasive disease in humans.

  4. Results indicate that hypermethylation of tumor suppressor protein (show TP53 Proteins) RASSF1A and docking protein 1 (DOK1 (show DOK1 Proteins)) contributes to hepatocarcinogenesis and is associated to clinicopathological characteristics.

  5. RASSF1 acts to restrict EMT (show ITK Proteins) and invasion by indirectly controlling YAP (show YAP1 Proteins) nuclear shuttling.

  6. Data indicate tumor suppressors TP73 (show TP73 Proteins), RASSF1A, MLH1 (show MLH1 Proteins) and BRCA1 as possible biomarkers to distinguish Pleomorphic invasive lobular cancer (pleomorphic ILC (show CCL27 Proteins)} from classic ILC (show CCL27 Proteins) and infiltrative ductal cancer (IDC (show LMNA Proteins)).

  7. Interaction between HPV infection and RASSF1A promoter methylation is associated with the development of cervical cancers.

  8. Hypermethylation of RASSF1A gene promoter is associated with esophageal squamous cell carcinoma.

  9. RASSF1A promotes the translocation of cytosolic PRMT5 (show PRMT5 Proteins) to microtubules.PRMT5 co-localizes with RASSF1A on stabilized microtubules.

  10. Tumor-adjacent tissues showed higher methylation status of RASSF1A, HIN-1 (show OTUD4 Proteins) and MGMT (show MGMT Proteins) promoters.

Mouse (Murine) Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) interaction partners

  1. essential role of RASSF1A in regulating TNF-alpha (show TNF Proteins) signalling in cardiomyocytes, with RASSF1A being key in the formation of the TNFR (show TNFRSF1A Proteins) complex and in signal transmission to the downstream targets

  2. RASSF1A may function to interfere and restrict TLR-driven activation of NF-kappaB (show NFKB1 Proteins) and is essential for protection against inflammation-induced injury.

  3. nickel-smelting fumes upregulated the expression of RASSF1A. This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.

  4. Loss of RASSF1A synergizes with deregulated RUNX2 (show RUNX2 Proteins) signaling in tumorigenesis.

  5. Concomitant with the loss of Rassf1a, the loss of p53 (show TP53 Proteins) (which causes unrestrained propagation of tetraploids into aneuploid cells) further undermines genomic stability and accelerates tumorigenesis.

  6. Data show that methylation of CCND-2 (show CCND2 Proteins), p16, RAR-beta (show RARB Proteins) and RASSF-1a was significantly more prevalent in tumor than in normal tissue specimens.

  7. Rassf1A acts as a tumor suppressor gene.

  8. cooperation between inactivation of Rassf1a and Apc (show APC Proteins) resulting in accelerated intestinal tumourigenesis.

  9. RASSF1A mediates p21Cip1/Waf1 (show CDKN1A Proteins)-dependent cell cycle arrest and senescence through modulation of the Raf (show RAF1 Proteins)-MEK (show MDK Proteins)-ERK (show EPHB2 Proteins) pathway and inhibition of Akt (show AKT1 Proteins).

  10. data establish RASSF1A as a novel inhibitor of cardiac hypertrophy by modulating the extracellular regulated kinase 1/2 pathway.

Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) Protein Profile

Protein Summary

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Gene names and symbols associated with RASSF1

  • nitrogen permease regulator-like 2 (S. cerevisiae) (NPRL2)
  • Ras association (RalGDS/AF-6) domain family 1 (rassf1)
  • Ras association (RalGDS/AF-6) domain family member 1 (RASSF1)
  • rassf1 (Smp_157340)
  • Ras association (RalGDS/AF-6) domain family member 1 (rassf1)
  • Ras association (RalGDS/AF-6) domain family member 1 (Rassf1)
  • 123F2 protein
  • AA536941 protein
  • AU044980 protein
  • NORE2A protein
  • RASSF1 protein
  • Rassf1A protein
  • Rassf1B protein
  • Rassf1C protein
  • RDA32 protein
  • REH3P21 protein
  • wu:fc17f02 protein
  • zgc:92505 protein
  • zgc:112224 protein

Protein level used designations for RASSF1

Ras association (RalGDS/AF-6) domain family 1 , Ras association (RalGDS/AF-6) domain family member 1 , ras association domain-containing protein 1 , Ras association domain family 1 , rassf1 , WUGSC:H_LUCA12.5 , cardiac-specific ras association domain family 1 protein , pancreas-specific ras association domain family 1 protein , tumor suppressor protein RDA32 , 123F protein , RASSF1A tumor suppressor , protein 123F2

GENE ID SPECIES
425132 Gallus gallus
447811 Danio rerio
702385 Macaca mulatta
744944 Pan troglodytes
8344706 Schistosoma mansoni
100036863 Xenopus laevis
100302080 Ovis aries
11186 Homo sapiens
56289 Mus musculus
363140 Rattus norvegicus
607929 Canis lupus familiaris
510276 Bos taurus
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