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RASSF1 encodes a protein similar to the RAS effector proteins. Additionally we are shipping Ras Association (RalGDS/AF-6) Domain Family Member 1 Proteins (8) and Ras Association (RalGDS/AF-6) Domain Family Member 1 Kits (3) and many more products for this protein.
Showing 10 out of 141 products:
Human Monoclonal RASSF1 Primary Antibody for ICC, ELISA - ABIN165456
Agathanggelou, Cooper, Latif: Role of the Ras-association domain family 1 tumor suppressor gene in human cancers. in Cancer research 2005
Show all 4 references for 165456
Human Monoclonal RASSF1 Primary Antibody for EIA, IF - ABIN121164
Dammann, Schagdarsurengin, Seidel, Strunnikova, Rastetter, Baier, Pfeifer: The tumor suppressor RASSF1A in human carcinogenesis: an update. in Histology and histopathology 2005
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Human Polyclonal RASSF1 Primary Antibody for IF (p), IHC (p) - ABIN673764
Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010
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Mouse (Murine) Polyclonal RASSF1 Primary Antibody for ELISA, WB - ABIN190784
Yan, Venkataramu, Ibrahim, Liu, Shen, Diaz, Centeno, Weber, Leu, Shapiro, Eng, Yeatman, Huang: Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Human Monoclonal RASSF1 Primary Antibody for FACS, ICC - ABIN4349434
Joo, Kim, Park, Yoo, Choe, Kim, Lee, Kim, Bak: CpG island promoter hypermethylation of Ras association domain family 1A gene contributes to gastric carcinogenesis. in Molecular medicine reports 2015
The main finding of this study was the significant association between RASSF1A promoter methylation and increased EC risk.
Data suggest that the overexpression of DNMT3B4 may play an important role in human kidney tumorigenesis through chromosomal instability and methylation of RASSF1A.
Methylation status of the RASSF1A gene promoter was strongly related to melanoma susceptibility but no significant difference was found between RASSF1A gene promoter methylation and the prognosis and clinical-pathological features of melanoma.
In response to TGF-beta (show TGFB1 Antibodies), RASSF1A is recruited to TGF-beta (show TGFB1 Antibodies) receptor I and targeted for degradation by the co-recruited E3 ubiquitin ligase (show MUL1 Antibodies) ITCH. RASSF1A degradation is necessary to permit Hippo pathway effector YAP1 (show YAP1 Antibodies) association with SMADs and subsequent nuclear translocation of receptor-activated SMAD2 (show SMAD2 Antibodies).
Our results suggest a multifactorial role of RASSF1A in suppression of liver carcinogenesis
For the first time, we performed analysis of DNA methylation (show HELLS Antibodies) in SMARCB1/INI1 (show SMARCB1 Antibodies)-deficient sinonasal carcinomas, reporting on significantly higher methylation of RASSF1 gene in this neoplasm.
High methylation in the RASSF1A promoter region is associated with lung cancer.
GSTP1 (show GSTP1 Antibodies), APC (show APC Antibodies) and RASSF1 gene methylation in prostate cancer samples: comparative analysis of MS-HRM method and Infinium HumanMethylation450 BeadChip beadchiparray diagnostic value
Compared with adjacent normal tissues, the methylation frequencies of WIF-1 (show WIF1 Antibodies), RASSF1A, and CDH13 (show CDH13 Antibodies) genes were significantly higher but the mRNA levels of these 3 genes were significantly lower in EC tissues. The survival rates of patients with WIF-1 (show WIF1 Antibodies), RASSF1A, and CDH13 (show CDH13 Antibodies) methylations were significantly lower than those of patients without methylation
The presence of higher RASSF1A methylation levels in fine-needle aspiration cytology specimens of nodular goitre may be useful in the assessment of oncological risk.
essential role of RASSF1A in regulating TNF-alpha (show TNF Antibodies) signalling in cardiomyocytes, with RASSF1A being key in the formation of the TNFR (show TNFRSF1A Antibodies) complex and in signal transmission to the downstream targets
RASSF1A may function to interfere and restrict TLR-driven activation of NF-kappaB (show NFKB1 Antibodies) and is essential for protection against inflammation-induced injury.
nickel-smelting fumes upregulated the expression of RASSF1A. This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.
Loss of RASSF1A synergizes with deregulated RUNX2 (show RUNX2 Antibodies) signaling in tumorigenesis.
Concomitant with the loss of Rassf1a, the loss of p53 (show TP53 Antibodies) (which causes unrestrained propagation of tetraploids into aneuploid cells) further undermines genomic stability and accelerates tumorigenesis.
Data show that methylation of CCND-2 (show CCND2 Antibodies), p16 (show CDKN2A Antibodies), RAR-beta (show RARB Antibodies) and RASSF-1a was significantly more prevalent in tumor than in normal tissue specimens.
Rassf1A acts as a tumor suppressor gene.
cooperation between inactivation of Rassf1a and Apc (show APC Antibodies) resulting in accelerated intestinal tumourigenesis.
RASSF1A mediates p21Cip1/Waf1 (show CDKN1A Antibodies)-dependent cell cycle arrest and senescence through modulation of the Raf (show RAF1 Antibodies)-MEK (show MDK Antibodies)-ERK (show EPHB2 Antibodies) pathway and inhibition of Akt (show AKT1 Antibodies).
data establish RASSF1A as a novel inhibitor of cardiac hypertrophy by modulating the extracellular regulated kinase 1/2 pathway.
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Ras association (RalGDS/AF-6) domain family 1
, Ras association (RalGDS/AF-6) domain family member 1
, ras association domain-containing protein 1
, Ras association domain family 1
, cardiac-specific ras association domain family 1 protein
, pancreas-specific ras association domain family 1 protein
, tumor suppressor protein RDA32
, 123F protein
, RASSF1A tumor suppressor
, protein 123F2