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Mediator of localized membrane signals. Additionally we are shipping and many more products for this protein.
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Human Polyclonal RAPH1 Primary Antibody for IHC, IHC (p) - ABIN4349375
Boucrot, Ferreira, Almeida-Souza, Debard, Vallis, Howard, Bertot, Sauvonnet, McMahon: Endophilin marks and controls a clathrin-independent endocytic pathway. in Nature 2015
The human RAPH1 gene is the CHE2 locus.
these studies demonstrate an insight into how the Lpd (show ACSBG1 Antibodies)-PH domain regulates cellular signals in a PI(3,4)P2 dependent manner.
Disruption of the RIAM (show APBB1IP Antibodies)/lamellipodin-integrin-talin complex markedly impairs cell migration.
The authors propose that Lpd delivers Ena/VASP proteins to growing barbed ends and increases their actin polymerase activity by tethering them to actin filaments.
These data indicate a possible role for Lpd in the actin-based movement and the cell-to-cell spread of L. monocytogenes.
The results suggest that although the RAPH1 gene was deleted or amplified in all samples, the Lpd (show ACSBG1 Antibodies) does not seem to play a major role in tumorigenesis of mammary carcinomas.
this study suggests a novel mechanism in which Lpd mediates EGFR endocytosis via Mena downstream of endophilin.
The crystal structure of Lpd cc-RA-PH presents a molecular model of Lpd enhances actin polymerization by oligomerization via two intermolecular contact sites.
results of this study suggested that that PI(3,4)P2, Lpd (show ACSBG1 Antibodies), and Ena/VASP (show VASP Antibodies) are involved in the process movement of multipolar migrating cells.
Nephrin (show NPHS1 Antibodies) ligation resulted in abnormal morphology of actin tails in human podocytes when Ship2 (show INPPL1 Antibodies), Filamin (show FLNA Antibodies) or Lamellipodin were individually knocked down.
Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion.
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 18
, amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 9
, amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein
, amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein
, proline-rich EVH1 ligand 2
, ras-associated and pleckstrin homology domains-containing protein 1