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Ras Association Domain-Containing Protein 6 Proteins (RASSF6)

RASSF6 encodes a member of the Ras-association domain family (RASSF). Additionally we are shipping RASSF6 Antibodies (51) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RASSF6 166824 Q6ZTQ3
RASSF6 73246 Q80UQ2
RASSF6 305251 Q4QR82
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Top RASSF6 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,924.17
Details

RASSF6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

Rat (Rattus)

More Proteins for Ras Association Domain-Containing Protein 6 (RASSF6) Interaction Partners

Human Ras Association Domain-Containing Protein 6 (RASSF6) interaction partners

  1. Mechanistic investigation shows that RASSF6 triggers p21(Cip1/Waf1 (show CDKN1A Proteins)) accumulation to induce G 1 cell cycle arrest and promote apoptosis upon exposure to pro-apoptotic agents, and both of these mechanisms appear to be mediated by activated JNK (show MAPK8 Proteins) signaling.

  2. RASSF6 expression is an independent biomarker of an unfavorable prognosis in patients with pancreatic ductal adenocarcinoma.

  3. RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cells.RASSF6 exhibits the highest frequency of inactivation in melanoma and in melanoma brain metastases.

  4. downregulation of RASSF6 in highly metastatic nasopharyngeal carcinoma cells contributed to their treatment resistance

  5. RASSF6-induced apoptosis partially depends on p53 (show TP53 Proteins). RASSF6 binds MDM2 (show MDM2 Proteins) and facilitates its ubiquitination. RASSF6 depletion blocks the increase of p53 (show TP53 Proteins) in response to UV exposure and up-regulation of p53 (show TP53 Proteins) target genes.

  6. The RASSF gene family members RASSF5 (show RASSF5 Proteins), RASSF6 and RASSF7 show frequent DNA methylation (show HELLS Proteins) in neuroblastoma (show ARHGEF16 Proteins).

  7. Decreased expression of RASSF6 is associated with gastric cancer.

  8. These findings indicate that RASSF6 is implicated in apoptosis in HeLa cells and that it triggers both caspase (show CASP3 Proteins)-dependent and caspase (show CASP3 Proteins)-independent pathways.

  9. Demonstrates properties of a Ras effector and tumor suppressor but exhibits biological properties that are unique and distinct from those of other family members.

  10. Sequencing revealed RASSF6 and RASSF10 were the only RASSF members with a high frequency of leukaemia-specific methylation.

Mouse (Murine) Ras Association Domain-Containing Protein 6 (RASSF6) interaction partners

  1. RASSF6 expression in adipocytes is down-regulated by interaction with macrophages.

  2. Demonstrates properties of a Ras effector and tumor suppressor but exhibits biological properties that are unique and distinct from those of other family members.

RASSF6 Protein Profile

Protein Summary

This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms.

Gene names and symbols associated with RASSF6

  • Ras association (RalGDS/AF-6) domain family 6 (rassf6)
  • Ras association (RalGDS/AF-6) domain family member 6 (RASSF6)
  • Ras association (RalGDS/AF-6) domain family member 6 (Rassf6)
  • 1600016B17Rik protein
  • im:7154480 protein
  • si:dz57f23.2 protein
  • zgc:136957 protein

Protein level used designations for RASSF6

ras association domain-containing protein 6 , Ras association (RalGDS/AF-6) domain family 6 , putative RAS binding protein

GENE ID SPECIES
751594 Danio rerio
166824 Homo sapiens
73246 Mus musculus
305251 Rattus norvegicus
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