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RASSF6 encodes a member of the Ras-association domain family (RASSF). Additionally we are shipping RASSF6 Antibodies (55) and many more products for this protein.
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Mechanistic investigation shows that RASSF6 triggers p21(Cip1/Waf1 (show CDKN1A Proteins)) accumulation to induce G 1 cell cycle arrest and promote apoptosis upon exposure to pro-apoptotic agents, and both of these mechanisms appear to be mediated by activated JNK (show MAPK8 Proteins) signaling.
RASSF6 expression is an independent biomarker of an unfavorable prognosis in patients with pancreatic ductal adenocarcinoma.
RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cells.RASSF6 exhibits the highest frequency of inactivation in melanoma and in melanoma brain metastases.
downregulation of RASSF6 in highly metastatic nasopharyngeal carcinoma cells contributed to their treatment resistance
RASSF6-induced apoptosis partially depends on p53 (show TP53 Proteins). RASSF6 binds MDM2 (show MDM2 Proteins) and facilitates its ubiquitination. RASSF6 depletion blocks the increase of p53 (show TP53 Proteins) in response to UV exposure and up-regulation of p53 (show TP53 Proteins) target genes.
The RASSF gene family members RASSF5 (show RASSF5 Proteins), RASSF6 and RASSF7 show frequent DNA methylation (show HELLS Proteins) in neuroblastoma (show ARHGEF16 Proteins).
Decreased expression of RASSF6 is associated with gastric cancer.
These findings indicate that RASSF6 is implicated in apoptosis in HeLa cells and that it triggers both caspase (show CASP3 Proteins)-dependent and caspase (show CASP3 Proteins)-independent pathways.
Demonstrates properties of a Ras effector and tumor suppressor but exhibits biological properties that are unique and distinct from those of other family members.
Sequencing revealed RASSF6 and RASSF10 were the only RASSF members with a high frequency of leukaemia-specific methylation.
RASSF6 expression in adipocytes is down-regulated by interaction with macrophages.
This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms.
ras association domain-containing protein 6
, Ras association (RalGDS/AF-6) domain family 6
, putative RAS binding protein