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RASSF6 encodes a member of the Ras-association domain family (RASSF). Additionally we are shipping RASSF6 Proteins (3) and many more products for this protein.
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Human Polyclonal RASSF6 Primary Antibody for ELISA, WB - ABIN314334
Allen, Donninger, Vos, Eckfeld, Hesson, Gordon, Birrer, Latif, Clark: RASSF6 is a novel member of the RASSF family of tumor suppressors. in Oncogene 2007
RASSF6 and RASSF10 were frequently hypermethylated in the samples at the time of diagnosis of adult acute lymphoblastic leukemia patients
Overexpression or silencing of RASSF6 could partially reverse the effects of the overexpression or repression of miR (show MLXIP Antibodies)-181a-5p on GC progress caused by activation of the MAKP pathway in vitro and in vivo.
Results suggest that down-regulation of RASSF2 (show RASSF2 Antibodies), and RASSF6 is a tumor-specific phenomenon and their inactivation through CpG island methylation may play important roles in gastric cardia carcinogenesis.
Mechanistic investigation shows that RASSF6 triggers p21(Cip1/Waf1 (show CDKN1A Antibodies)) accumulation to induce G 1 cell cycle arrest and promote apoptosis upon exposure to pro-apoptotic agents, and both of these mechanisms appear to be mediated by activated JNK (show MAPK8 Antibodies) signaling.
RASSF6 expression is an independent biomarker of an unfavorable prognosis in patients with pancreatic ductal adenocarcinoma.
RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cells.RASSF6 exhibits the highest frequency of inactivation in melanoma and in melanoma brain metastases.
downregulation of RASSF6 in highly metastatic nasopharyngeal carcinoma cells contributed to their treatment resistance
RASSF6-induced apoptosis partially depends on p53 (show TP53 Antibodies). RASSF6 binds MDM2 (show MDM2 Antibodies) and facilitates its ubiquitination. RASSF6 depletion blocks the increase of p53 (show TP53 Antibodies) in response to UV exposure and up-regulation of p53 (show TP53 Antibodies) target genes.
The RASSF gene family members RASSF5 (show RASSF5 Antibodies), RASSF6 and RASSF7 show frequent DNA methylation (show HELLS Antibodies) in neuroblastoma (show ARHGEF16 Antibodies).
Decreased expression of RASSF6 is associated with gastric cancer.
RASSF6 expression in adipocytes is down-regulated by interaction with macrophages.
Demonstrates properties of a Ras effector and tumor suppressor but exhibits biological properties that are unique and distinct from those of other family members.
This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms.
ras association domain-containing protein 6
, Ras association (RalGDS/AF-6) domain family 6
, putative RAS binding protein