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Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.. Additionally we are shipping Radil Antibodies (39) and and many more products for this protein.
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Here, we identify a novel effector of the small GTPase (show RACGAP1 Proteins) Rap (show LRPAP1 Proteins), called RADIL, and show that it is required for cell adhesion and migration
Studies indicate that Radil regulates neutrophil adhesion and motility by linking Rap1 to beta2-integrin activation. +++ ERROR +++ studies establish that Radil regulates neutrophil adhesion and motility by linking Rap1 to beta2-integrin activation.
It was shown that KIF14 associates with the PDZ domain of Radil and negatively regulates Rap1 (show RABGEF1 Proteins)-mediated inside-out integrin activation by tethering Radil on microtubules. Radil is also important for breast cancer cell proliferation and metastasis.
Gbetagamma subunits enter in a protein complex with activated Rap1a (show RAP1A Proteins) and its effector Radil; this complex is required downstream of receptor stimulation for the activation of integrins and the positive modulation of cell-matrix adhesiveness.
Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.
ras-associating and dilute domain-containing protein
, Rap GTPase interactor
, Ras association and DIL domains
, ras-associating and dilute domain-containing protein-like
, Rap GTPase interactor, RADIL