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RHOT2 encodes a member of the Rho family of GTPases. Additionally we are shipping Ras Homolog Gene Family, Member T2 Proteins (7) and Ras Homolog Gene Family, Member T2 Kits (3) and many more products for this protein.
Showing 10 out of 38 products:
Human Polyclonal RHOT2 Primary Antibody for ICC, IF - ABIN4350453
Birsa, Norkett, Wauer, Mevissen, Wu, Foltynie, Bhatia, Hirst, Komander, Plun-Favreau, Kittler: Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase. in The Journal of biological chemistry 2014
Miro and Cenp-F (show CENPF Antibodies) promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells.
The Miro2-mediated mitochondrial transport in neurons and recently highlighted involvement of Miro2 proteins in mitochondrial turnover, emerging as a key process affected in neurodegeneration.
Study shows that both PINK1 (show PINK1 Antibodies) and Parkin (show PARK2 Antibodies) halt mitochondrial movement; PINK1 (show PINK1 Antibodies) phosphorylates Miro (1 (show RHOT1 Antibodies) and 2) and thereby initiates the rapid degradation of Miro through a Parkin (show PARK2 Antibodies)- and proteasome-dependent pathway.
Moreover, we show that Miro interacts with the Kinesin-binding proteins, GRIF-1 (show TRAK2 Antibodies) and OIP106 (show TRAK1 Antibodies), suggesting that the Miro GTPases form a link between the mitochondria and the trafficking apparatus of the microtubules.
Miro proteins serve as a [Ca(2 (show CA2 Antibodies)+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria.
Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro 1 (show RHOT1 Antibodies)/2 and Trak2 (show TRAK2 Antibodies).
molecular cloning and characterization of a novel mouse cDNA encoding a putative atypical GTPase (show RACGAP1 Antibodies) protein, Arht2
This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics.
ras homolog gene family, member T2
, mitochondrial Rho GTPase 2-like
, mitochondrial Rho (MIRO) GTPase 2
, mitochondrial Rho GTPase 2
, miro protein
, mitochondrial Rho 2
, ras homolog gene family member T2
, rho GTPase