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RHOT2 encodes a member of the Rho family of GTPases. Additionally we are shipping Ras Homolog Gene Family, Member T2 Antibodies (37) and many more products for this protein.
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Miro and Cenp-F (show CENPF Proteins) promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells.
The Miro2-mediated mitochondrial transport in neurons and recently highlighted involvement of Miro2 proteins in mitochondrial turnover, emerging as a key process affected in neurodegeneration.
Study shows that both PINK1 (show PINK1 Proteins) and Parkin (show PARK2 Proteins) halt mitochondrial movement; PINK1 (show PINK1 Proteins) phosphorylates Miro (1 (show RHOT1 Proteins) and 2) and thereby initiates the rapid degradation of Miro through a Parkin (show PARK2 Proteins)- and proteasome-dependent pathway.
Moreover, we show that Miro interacts with the Kinesin-binding proteins, GRIF-1 and OIP106 (show TRAK1 Proteins), suggesting that the Miro GTPases form a link between the mitochondria and the trafficking apparatus of the microtubules.
Miro proteins serve as a [Ca(2 (show CA2 Proteins)+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria.
Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro 1/2 and Trak2.
molecular cloning and characterization of a novel mouse cDNA encoding a putative atypical GTPase (show RACGAP1 Proteins) protein, Arht2
This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics.
ras homolog gene family, member T2
, mitochondrial Rho GTPase 2-like
, mitochondrial Rho (MIRO) GTPase 2
, mitochondrial Rho GTPase 2
, miro protein
, mitochondrial Rho 2
, ras homolog gene family member T2
, rho GTPase