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RHOU encodes a member of the Rho family of GTPases. Additionally we are shipping RHOU Proteins (3) and many more products for this protein.
Showing 10 out of 41 products:
Human Polyclonal RHOU Primary Antibody for ELISA - ABIN249477
Tao, Pennica, Xu, Kalejta, Levine: Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. in Genes & development 2001
PAK4 (show PAK4 Antibodies) and RhoU cooperate to drive adhesion turnover and promote cell migration.
Data indicate that upregulated miR (show MLXIP Antibodies)-126 upon coxsackievirus B3 (CVB3) infection targets SPRED1 (show SPRED1 Antibodies), LRP6 (show LRP6 Antibodies), and WRCH1 genes, mediating cross-talk between ERK1/2 (show MAPK1/3 Antibodies) and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathways, and thus promoting viral replication.
multiple upstream signals may converge on Wrch1 directly through its SH3 domain (show ITSN1 Antibodies)-binding properties
results indicate that NOTCH1 (show NOTCH1 Antibodies) mutation stimulates T-cell acute lymphoblastic leukaemia cell migration through RhoU upregulation that could contribute to the leukaemia cell dissemination
data suggest a unique regulatory mechanism by which RhoU interaction with SH3 adaptor proteins might serve to integrate growth factor receptor (show RYK Antibodies) signaling with RhoU activatio
A screen for Wrch-1 binding-partners identified the novel RhoGAP protein (show ARHGAP26 Antibodies), ARHGAP30 (show ARHGAP30 Antibodies), as a Wrch-1 interactor.
Studies revealed a requirement for serum-stimulated tyrosine phosphorylation of Wrch1 at residue Y254 within its C-terminal membrane targeting domain, mediated by the nonreceptor tyrosine kinase (show TXK Antibodies) Src (show SRC Antibodies).
Down regulation of WRCH1 by estradiol in breast cancer and altered expression of WRCH1 is associated with other cancers
G28K cDNA encodes a protein of 258 amino acids with homology to the cell division cycle 42/G25K protein; this gene is located at 1q42.11-q42.3; G28K was abundantly expressed in the stomach and the small intestine
These data suggest that Wrch-1 regulates cell migration by multiple mechanisms: on the one hand Wrch-1 controls focal adhesions by regulating myosin light chain and on the other hand Wrch-1 stimulates the activation of Akt (show AKT1 Antibodies) and JNK (show MAPK8 Antibodies).
Rhou activity maintains the epithelial architecture of the endoderm progenitors, and its downregulation accompanies the transition of the columnar epithelium in the embryonic foregut to a multilayered cell sheet during organ formation.
G28K was differentially expressed in the small intestines; interstitial cells of Cajal within the small intestine expressed mRNA for G28K; downregulated in the jejunum of W/W V mice.
Wrch-1 membrane association, subcellular localization, and biological activity are mediated by a novel membrane-targeting mechanism distinct from that of Cdc42 (show CDC42 Antibodies) and other isoprenylated Rho family GTPases
Wrch1 collaborates with FAK2 (show PTK2B Antibodies) and Src (show SRC Antibodies) in regulating cytoskeletal dynamics.
This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.
ras homolog gene family, member U
, CDC42-like GTPase 1
, GTP-binding protein SB128
, GTP-binding protein like 1
, Ryu GTPase
, ras-like gene family member U
, rho GTPase-like protein ARHU
, rho-related GTP-binding protein RhoU
, wnt-1 responsive Cdc42 homolog 1
, Ras-like protein member U
, Wnt1 responsive Cdc42 homolog