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RIN3 is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases (see RAB5A\; MIM 179512) (Kajiho et al., 2003 [PubMed 12972505]).[supplied by OMIM, Mar 2008].. Additionally we are shipping RIN3 Antibodies (17) and many more products for this protein.
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RIN3 may contribute to Paget's disease of bone susceptibility by affecting osteoclast function.
discovered novel interaction candidates for CD2AP (show Cd2ap Proteins) and characterized subtle yet significant differences in the recognition preferences of its three SH3 domains for c-CBL (show CBL Proteins), ALIX (show PDCD6IP Proteins), and RIN3
The study reports a novel association between a variant within RIN3 and lower limb-bone mineral density and note its previous association with risk of Paget's disease.
RIN3 is a negative regulator of mast cell responses to SCF (show KITLG Proteins)
RIN3 specifically acts as a GEF (show SLC2A4RG Proteins) for Rab31 (show RAB31 Proteins).
RIN3 biochemically characterized as the stimulator and stabilizer for GTP (show AK3 Proteins)-Rab5 (show RAB5A Proteins) plays an important role in the transport pathway from plasma membrane to early endosomes
Tyrosine-phosphorylation signals are involved in the RIN3 activation and translocation to early endocytic vesicles.
RIN3 is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases (see RAB5A\; MIM 179512) (Kajiho et al., 2003
ras and Rab interactor 3
, Ras and Rab interactor 3
, ras and Rab interactor 3-like
, RAB5 interacting protein 3
, ras interaction/interference protein 3
, Ras interaction/interference protein 3