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Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. Additionally we are shipping and many more products for this protein.
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Human Polyclonal RAC1 Primary Antibody for IHC - ABIN350778
Ambruso, Knall, Abell, Panepinto, Kurkchubasche, Thurman, Gonzalez-Aller, Hiester, deBoer, Harbeck, Oyer, Johnson, Roos: Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. in Proceedings of the National Academy of Sciences of the United States of America 2000
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Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (By similarity). Stimulates PKN2 kinase activity (By similarity). In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts.
, ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
, rho family, small GTP binding protein Rac1
, ras-related C3 botulinum toxin substrate 1
, rac2 GTP-binding protein