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The protein encoded by RECQL5 is a helicase that is important for genome stability. Additionally we are shipping RECQL5 Kits (4) and RECQL5 Proteins (3) and many more products for this protein.
Showing 10 out of 63 products:
Human Polyclonal RECQL5 Primary Antibody for WB - ABIN1881739
Schwendener, Raynard, Paliwal, Cheng, Kanagaraj, Shevelev, Stark, Sung, Janscak: Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity. in The Journal of biological chemistry 2010
Show all 5 references for ABIN1881739
Cow (Bovine) Polyclonal RECQL5 Primary Antibody for WB - ABIN2775189
Garcia, Liu, Jiricny, West, Janscak: Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide. in The EMBO journal 2004
RECQL5 is a critical regulator of genome stability in myeloproliferative neoplasms and demonstrate that replication stress-associated cytotoxicity can be amplified specifically in JAK2V617F mutant cells through RECQL5-targeted synthetic lethality.
Expression of RECQL5 in breast cancer can drive proliferation supporting an oncogenic function for RECQL5 in breast cancer. RECQL5 is a promising biomarker in breast cancer.
RecQ5 prevents transcription associated genome instability by facilitating PIAS1 (show PIAS1 Antibodies)-SRSF1 (show SRSF1 Antibodies) ligase complex sumoylation of DNA topoisomerase 1 (show TOP1 Antibodies).
results suggested RECQL5 as a tumor suppressor in osteosarcoma and may be a potential therapeutic target for osteosarcoma treatment
PARylation is involved in the recruitment of RECQL5 and WRN to laser-induced DNA damage and RECQL5 and WRN have differential responses to PARylated PARP1 and Poly(ADP-ribose).
The RECQL5 genetic polymorphism was associated with osteosarcoma in a Chinese population.
The present study indicated that the RECQL5 genetic polymorphism and haplotypes were associated with breast cancer in a Chinese population.
RECQL5 as a major determinant for camptothecin resistance in colorectal cancer cells.
The data presented here provide evidence that RECQL5 plays a general role in the control of transcript elongation in human cells. In its absence, transcript elongation rates increase, the distribution profile of RNAPII is markedly altered across the genome, and higher levels of RNAPII pausing or arrest (i.e., transcription stress) are detected.
RECQL5 genetic polymorphisms were associated with osteosarcoma in a Chinese population.
Recql5 has a tumor suppressor role in the gastrointestinal tract of Apc (show APC Antibodies)(min) mice.
Recql5-deficient cells exhibit elevated frequencies of spontaneous DNA double-strand breaks and homologous recombination (
Data suggest that Recql5 helps maintain active DNA replication to prevent collapse of replication forks and accumulation of DSBs, preserve genome integrity and prevent cell death after replication stress due to topoisomerase I (show TOP1 Antibodies) poisoning.
The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene.
ATP-dependent DNA helicase Q5
, RecQ protein-like 5
, ATP-dependent DNA helicase Q5-like
, DNA helicase, RecQ-like type 5