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The protein encoded by PTPRT is a member of the protein tyrosine phosphatase (PTP) family. Additionally we are shipping PTPRT Antibodies (28) and PTPRT Kits (2) and many more products for this protein.
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PTPRT promoter methylation is significantly associated with sensitivity to STAT3 (show STAT3 Proteins) inhibition in HNSCC cells, suggesting that PTPRT promoter methylation may serve as a predictive biomarker for responsiveness to STAT3 (show STAT3 Proteins) inhibitors in clinical development
Data reported evidence that rs2866943 polymorphism in PTPRT 3'-UTR was involved in the occurrence of esophageal squamous cell carcinoma by acting as a protective factor while rs6029959 acts as a risk factor.
Data show that hepatitis B virus X protein mutant HBxDelta127 enhances proliferation of hepatoma cells through up-regulating miR (show MLXIP Proteins)-215 targeting protein tyrosine phosphatase (show ACP1 Proteins), receptor type T (PTPRT).
tumor-specific mutational events in the PTPRT gene can serve as direct drivers for tumor growth by inducing hyperactivation of STAT3 (show STAT3 Proteins), a potent oncogenic transcription factor and PTPRT substrate
[review] High-throughput mutational analysis identifies loss-of-function mutations in six PTPs (show PTS Proteins) in human colon cancers, providing critical cancer genetics evidence that PTPs (show PTS Proteins) can act as tumour suppressor genes.
Data show that paxillin (show PXN Proteins) is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin (show PXN Proteins) phosphorylation at tyrosine residue 88(Y88).
alterations of the PTPRT-mediated signaling pathway by PTPRT phosphatase domain mutation may not play a critical role in the development of common human cancers
STAT3 (show STAT3 Proteins) is a substrate of receptor protein tyrosine phosphatase T
brain-specific (show CALY Proteins) PTPRT regulates synapse formation through interaction with cell adhesion molecules, and this function and the phosphatase activity are attenuated through tyrosine phosphorylation by the synaptic tyrosine kinase (show TXK Proteins) Fyn (show FYN Proteins).
Receptor protein tyrosine phosphatase rho (RPTPrho, gene symbol PTPRT) is a transmembrane protein expressed at high levels in the developing hippocampus, olfactory bulb, cortex, and cerebellum.
These studies implicate PTPRT-modulated STAT3 (show STAT3 Proteins) signaling in the regulation of high-fat diet-induced obesity
BCR (show BCR Proteins) is a novel substrate of PTPRT .
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
, receptor protein tyrosine phosphatase
, receptor-type tyrosine-protein phosphatase T
, receptor-type tyrosine-protein phosphatase rho
, receptor protein tyrosine phosphatase-rho