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Receptor-Associated Protein of The Synapse Proteins (RAPSN)

RAPSN encodes a member of a family of proteins that are receptor associated proteins of the synapse. Additionally we are shipping Receptor-Associated Protein of The Synapse Antibodies (37) and Receptor-Associated Protein of The Synapse Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RAPSN 5913 Q13702
RAPSN 19400 P12672
Rat RAPSN RAPSN 362161  
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Top Receptor-Associated Protein of The Synapse Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Torpedo californica His tag   1 mg Log in to see 56 to 66 Days
$3,142.33
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,142.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$498.21
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RAPSN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Receptor-Associated Protein of The Synapse (RAPSN) Interaction Partners

Human Receptor-Associated Protein of The Synapse (RAPSN) interaction partners

  1. These findings uncover a new link between rapsyn, lysosome positioning, exocytosis and plasma membrane integrity.

  2. a mutation of the RAPSN gene may have a role in development of congenital myasthenic syndrome after general anaesthesia [case report]

  3. Investigation of mutations in RAPSN determines that patients with congenital myasthenic syndrome can be misdiagnosed with seronegative myasthenia gravis.

  4. An allelic quantification on patient's DNA identified three novel multi-exon deletions of RAPSN.

  5. nAChR (show CHRNA4 Proteins) mobility in plasma membranes of myoblast cells during their differentiation to myotubes in the presence and absence of rapsyn

  6. Rapsyn mutations in humans cause endplate acetylcholine-receptor deficiency and myasthenic syndrome

  7. E-box mutations in the RAPSN promoter region may have a role in congenital myasthenic syndrome

  8. Four patients from four different families with RAPSN mutations and congenital myasthenic syndrome

  9. Rapsyn is essential for clustering the acetylcholine receptor at the postsynaptic membrane of the neuromuscular junction.

  10. recombination events may have occurred within the rapsyn gene and that this may have implications in the phenotypic expression of postsynaptic congenital myasthenic syndrome

Mouse (Murine) Receptor-Associated Protein of The Synapse (RAPSN) interaction partners

  1. Protein kinase CK2 (show CSNK2A1 Proteins) interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3gamma (show YWHAG Proteins), and Dok-7 (show DOK7 Proteins) proteins and phosphorylates the latter two.

  2. Plectin bridges acetylcholine receptors and intermediate filaments via direct interaction with the AChR-scaffolding protein rapsyn in an isoform-specific manner.

  3. Molecular modelling, immunoprecipitation and bimolecular fluorescence complementation approaches identify an alpha-helical stretch of rapsyn to be crucial for binding to the dimerisation and docking domain of PKA type I.

  4. typical anchoring proteins of central excitatory synapses coimmunoprecipitate and colocalize with rapsyn

  5. alpha-Actinin (show ACTN1 Proteins), rapsyn, and surface AChR form a ternary complex.

  6. nAChR (show CHRNA4 Proteins) mobility in plasma membranes of myoblast cells during their differentiation to myotubes in the presence and absence of rapsyn

  7. These results provide the first experimental evidence that rapsyn is a direct sequence-specific target of Kaiso (show ZBTB33 Proteins) and delta-catenin (show CTNND2 Proteins).

  8. Thus, the metabolic half-life of receptors at the synapse may be modulated by local changes in the subsynaptic ratio of rapsyn to AChR.

  9. Remarkable dynamism of rapsyn underlies stability and maintenance of the postsynaptic scaffold and suggests that the insertion of different postsynaptic proteins may be operating independently.

  10. Developmental increase in the amount of rapsyn per acetylcholine receptor promotes postsynaptic receptor packing and stability.

Receptor-Associated Protein of The Synapse (RAPSN) Protein Profile

Protein Summary

This gene encodes a member of a family of proteins that are receptor associated proteins of the synapse. The encoded protein contains a conserved cAMP-dependent protein kinase phosphorylation site, and plays a critical role in clustering and anchoring nicotinic acetylcholine receptors at synaptic sites by linking the receptors to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Mutations in this gene may play a role in postsynaptic congenital myasthenic syndromes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with RAPSN

  • receptor-associated protein of the synapse (RAPSN)
  • receptor-associated protein of the synapse (rapsn)
  • receptor-associated protein of the synapse (Rapsn)
  • receptor-associated protein of the synapse, 43kD (rapsn)
  • 43kDa protein
  • Nraps protein
  • Raps protein
  • RAPSN protein
  • rapsyn protein
  • RNF205 protein

Protein level used designations for RAPSN

receptor-associated protein of the synapse , 43 kD receptor-associated protein of the synapse , 43 kDa receptor-associated protein of the synapse-like , 43 kDa postsynaptic protein , 43 kDa receptor-associated protein of the synapse , acetylcholine receptor-associated 43 kDa protein , rapsyn , receptor-associated protein of the synapse, 43kD , 43 kda postsynaptic protein , RING finger protein 205 , acetylcholine receptor-associated 43 kda protein , 43kDa acetylcholine receptor-associated protein , receptor-associated protein of the synapse, 43 kDa , twitch once , two

GENE ID SPECIES
451705 Pan troglodytes
100051540 Equus caballus
100397914 Callithrix jacchus
100447845 Pongo abelii
100579467 Nomascus leucogenys
399137 Xenopus laevis
395986 Gallus gallus
5913 Homo sapiens
609725 Canis lupus familiaris
541061 Bos taurus
19400 Mus musculus
362161 Rattus norvegicus
352942 Danio rerio
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